Based largely on results from preclinical studies, the concept of a brain gut microbiome axis has been established, mediating bidirectional communication between the gut, its microbiome, and the nervous system. Limited data obtained in human beings suggest that alterations in these interactions may play a role in several brain gut disorders.We reviewed the preclinical and clinical literature related to the topic of brain gut microbiome interactions.Well-characterized bidirectional communication channels, involving neural, endocrine, and inflammatory mechanisms, exist between the gut and the brain. Communication through these channels may be modulated by variations in the permeability of the intestinal wall and the blood-brain barrier. Brain gut microbiome interactions are programmed during the first 3 years of life, including the prenatal period, but can be modulated by diet, medications, and stress throughout life. Based on correlational studies, alterations in these interactions have been implicated in the regulation of food intake, obesity, and in irritable bowel syndrome, even though causality remains to be established.Targets within the brain gut microbiome axis have the potential to become targets for novel drug development for brain gut disorders.

Vadim Osadchiy

Clair R Martin

Emeran A Mayer

Clinical Gastroenterology and Hepatology

临床胃肠病学和肝病学 (CGH) 的使命是为读者提供临床胃肠病学和肝病学的广泛主题，包括癌症、炎症性疾病、功能性胃肠疾病、营养、吸收的诊断、内窥镜、介入和治疗进展, 和分泌物。

The mission of Clinical Gastroenterology and Hepatology is to provide readers with a wide range of topics in clinical gastroenterology and hepatology. These topics include cancer, inflammatory diseases, functional gastrointestinal disorders, nutrition, diagnostic absorption, endoscopy, interventional procedures, and therapeutic advancements.

《Clinical Gastroenterology and Hepatology》的使命是为读者提供关于临床胃肠病学和肝病学的广泛主题。这些主题包括癌症、炎症性疾病、功能性胃肠疾病、营养、吸收的诊断、内窥镜检查、介入治疗和相关进展。

The Gut–Brain Axis and the Microbiome: Mechanisms and Clinical Implications

Targets within the brain gut microbiome axis have the potential to become targets for novel drug development for brain gut disorders.

Category	Quartile
医学	1
医学, 胃肠肝病学	1

The Gut–Brain Axis and the Microbiome: Mechanisms and Clinical Implications

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Category	Quartile
GASTROENTEROLOGY & HEPATOLOGY	1