A previous pharmacogenomic analysis identified cromolyn, an anti-allergic drug, as an effective anti-fibrotic agent that acts on hepatocytes and stellate cells. Furthermore, cromolyn was shown to be a G protein-coupled receptor 35 (GPR35) agonist. However, it has not been studied whether anti-fibrotic effects are mediated by GPR35. Therefore, in this study, the role of GPR35 in hepatic fibrosis was investigated through the use of lodoxamide, another anti-allergic drug and a potent GPR35 agonist. Longterm treatment with carbon tetrachloride induced hepatic fibrosis, which was inhibited by treatment with lodoxamide. Furthermore, CID2745687, a specific GPR35 antagonist, reversed lodoxamide-mediated anti-fibrotic effects. In addition, lodoxamide treatment showed significant effects on the mRNA expression of collagen Iα1, collagen Iα2, and TGF-β1 in the extracellular matrix. However, a transforming growth factor α (TGF-α) shedding assay revealed lodoxamide not to be a potent agonist of mouse GPR35 in vitro. Therefore, these results showed anti-fibrotic effects of lodoxamide in mice and raise concerns how lodoxamide protects against liver fibrosis in vivo and whether GPR35 is involved in the action.

Mi-Jeong Kim

Soo-Jin Park

So-Yeon Nam

Dong-Soon Im

Biomolecules & Therapeutics

BIOMOLECULES & THERAPEUTICS (BIOMOLECULES & THERAPEUTICS)（印刷 ISSN 1976-9148，在线 ISSN 2005-4483）是一份国际性的、同行评审的、开放获取的期刊，涵盖与生物活性分子和治疗相关的药理学和毒理学领域。 1993年创刊为《应用药理学杂志》（ISSN 1225-6110），2008年更名为《BIOMOLECULES & THERAPEUTICS》（BIOMOL THER：缩写形式）（第16卷第1期）。它在一月、三月、五月、七月、九月和十一月出版双月刊。所有手稿都应具有创造性、内容丰富，并有助于新药的开发。发表以下类别的文章：评论文章和研究文章。

Biomolecules and Therapeutics (Print ISSN 1976-9148, Online ISSN 2005-4483) is an international, peer-reviewed, open-access journal that focuses on pharmacology and toxicology related to bioactive molecules and their therapeutic applications. Established in 1993 as the Journal of Applied Pharmacology (ISSN 1225-6110), it was renamed Biomolecules and Therapeutics (BIOMOL THER: abbreviated form) in 2008. The journal publishes six issues per year in January, March, May, July, September, and November. All submitted manuscripts should be innovative, content-rich, and contribute to the development of new drugs. The journal accepts the publication of both review articles and research articles.

《Biomolecules and Therapeutics》（印刷 ISSN 1976-9148，在线 ISSN 2005-4483）是一份国际性的、同行评审的开放获取期刊，专注于生物活性分子及其治疗相关的药理学和毒理学领域。该期刊创刊于1993年，最初名为《应用药理学杂志》（ISSN 1225-6110），并于2008年更名为《Biomolecules and Therapeutics》（BIOMOL THER：缩写形式），目前每年出版六期，分别在一月、三月、五月、七月、九月和十一月发行。所有提交的手稿应具备创新性、内容丰富，并对新药的开发有所贡献。期刊接受评论文章和研究文章的发表。

Biomolecules and Therapeutics

Lodoxamide Attenuates Hepatic Fibrosis in Mice: Involvement of GPR35

Results showed anti-fibrotic effects of lodoxamide in mice and raise concerns how lodoxamia protects against liver fibrosis in vivo and whether GPR35 is involved in the action.

Category	Quartile
医学	3
医学, 药学	3

Lodoxamide Attenuates Hepatic Fibrosis in Mice: Involvement of GPR35

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Category	Quartile
PHARMACOLOGY & PHARMACY	2