Posttranslational modifications affect almost all proteins and are critical to a well-functioning and diverse proteome; however, many modifications remain relatively unknown and unstudied. This paper will give a perspective on the rapidly developing, novel posttranslational modification called succinylation. This modification may be implicated in numerous diseases, such as hepatic, cardiac, and pulmonary diseases. Although the influences of this modification still remain poorly understood, we are confident that further research into succinylation will provide an enhanced understanding of the complex machinery within the mitochondria, as well as the imposing consequences associated with its dysfunction.

Matthew Alleyn

Mason Breitzig

Richard Lockey

Narasaiah Kolliputi

AJP Cell Physiology

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 致力于研究细胞和分子生理学的创新方法。使用细胞和分子方法阐明更高组织水平的生理控制机制的贡献也经常出现。鼓励涉及细胞膜、收缩系统、细胞器和膜通道、转运蛋白和泵的结构和功能的手稿。研究涉及细胞功能的综合调节，包括信号转导机制、发育、基因表达、细胞间相互作用以及病理生理状态的细胞生理学，也受到热切关注。特别欢迎将生物化学、生物物理学、分子生物学、形态学和免疫学方法应用于确定细胞生理学新原理的跨学科研究。

The American Journal of Physiology - Cell Physiology is dedicated to innovative research in cellular and molecular physiology. The journal encourages the use of cellular and molecular approaches to elucidate physiological control mechanisms at higher organizational levels. We welcome manuscripts that involve the structure and function of cell membranes, contractile systems, organelles, membrane channels, transport proteins, and pumps. Research topics include the integrated regulation of cellular functions, encompassing signal transduction mechanisms, development, gene expression, intercellular interactions, and cellular physiology in pathophysiological states. Furthermore, the journal particularly welcomes interdisciplinary studies that apply biochemistry, biophysics, molecular biology, morphology, and immunology methods to identify new principles in cellular physiology.

《American Journal of Physiology - Cell Physiology》致力于细胞和分子生理学的创新研究。期刊鼓励使用细胞和分子方法来阐明更高组织水平的生理控制机制。我们欢迎涉及细胞膜、收缩系统、细胞器、膜通道、转运蛋白和泵的结构与功能的研究手稿。研究内容包括细胞功能的综合调节，涵盖信号转导机制、发育、基因表达、细胞间相互作用以及病理生理状态下的细胞生理学。此外，期刊特别欢迎将生物化学、生物物理学、分子生物学、形态学和免疫学等方法应用于确定细胞生理学新原理的跨学科研究。

American Journal of Physiology - Cell Physiology

American Journal of Physiology-Cell Physiology

The dawn of succinylation: a posttranslational modification

A perspective on the rapidly developing, novel posttranslational modification called succinylation, which may be implicated in numerous diseases, such as hepatic, cardiac, and pulmonary diseases, is given.

Category	Quartile
生物学	2
生物学, 生理学	2
生物学, 细胞生物学	3

The dawn of succinylation: a posttranslational modification

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