DNA nanostructures hold great promise for various applications due to their remarkable properties, including programmable assembly, nanometric positional precision, and dynamic structural control. The past few decades have seen the development of various kinds of DNA nanostructures that can be employed as useful tools in fields such as chemistry, materials, biology, and medicine. Aptamers are short single-stranded nucleic acids that bind to specific targets with excellent selectivity and high affinity and play critical roles in molecular recognition. Recently, many attempts have been made to integrate aptamers with DNA nanostructures for a range of biological applications. This review starts with an introduction to the features of aptamer-functionalized DNA nanostructures. The discussion then focuses on recent progress (particularly during the last five years) in the applications of these nanostructures in areas such as biosensing, bioimaging, cancer therapy, and biophysics. Finally, challenges involved in the practical application of aptamer-functionalized DNA nanostructures are discussed, and perspectives on future directions for research into and applications of aptamer-functionalized DNA nanostructures are provided.

Xiaoyi Fu

Fangqi Peng

Jungyeon Lee

Qi Yang

Fei Zhang

Mengyi Xiong

Gezhi Kong

Hong-Min Meng

Guoliang Ke

Xiao-Bing Zhang

Topics in current chemistry (Cham)

当前化学主题对现代化学研究的当前和未来趋势进行了批判性评论。涵盖范围是化学科学的所有领域，包括与生物学、医学、物理学和材料科学等相关学科的接口。每个专题合集的目标是为学术界或工业界的非专业读者提供全面的深入了解正在出现的新研究领域，这对更大的科学受众感兴趣。

Topics in Current Chemistry provides critical reviews of current and future trends in modern chemical research. It covers all areas of chemical science, including interfaces with related disciplines such as biology, medicine, physics, and materials science. Each thematic collection aims to offer a comprehensive understanding of emerging research fields for non-specialist readers in academia or industry, appealing to a broader scientific audience.

《Topics in Current Chemistry》对现代化学研究的当前和未来趋势进行了深入的批判性评论。该期刊涵盖化学科学的所有领域，包括与生物学、医学、物理学和材料科学等相关学科的交叉领域。每个专题合集旨在为学术界和工业界的非专业读者提供对新兴研究领域的全面理解，以满足更广泛科学受众的兴趣。

Topics in Current Chemistry

Top Curr Chem (Cham)

Aptamer-Functionalized DNA Nanostructures for Biological Applications.

This review starts with an introduction to the features of aptamer-functionalized DNA nanostructures and focuses on recent progress in the applications of these nanostructure in areas such as biosensing, bioimaging, cancer therapy, and biophysics.

Category	Quartile
化学	2
化学, 化学综合	2

Aptamer-Functionalized DNA Nanostructures for Biological Applications.

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Journal Info

Category	Quartile
CHEMISTRY, MULTIDISCIPLINARY	1