To propose a common nomenclature to refer to individuals who fulfill the American College of Rheumatology classification criteria for systemic lupus erythematosus (SLE) during childhood or adolescence.The medical literature was reviewed for studies conducted in the target population between 1960 and December 2011 to obtain information about the terms used to refer to such children and adolescents. We reviewed the threshold ages used and disease features considered to discriminate these individuals from patients with onset of SLE during adulthood. Furthermore, the nomenclature used in other chronic diseases with onset during both childhood and adulthood was assessed.There was an astonishing variability in the age cutoffs used to define SLE onset prior to adulthood, ranging from 14-21 years, but most studies used age 18 years. The principal synonyms in the medical literature were SLE without reference to the age at onset of disease, childhood-onset SLE, juvenile SLE, and pediatric (or paediatric) SLE.Based on the definition of childhood, in analogy with other complex chronic diseases commencing prior to adulthood, and given the current absence of definite genetic variations that discriminate adults from children, the term childhood-onset SLE is proposed when referring to individuals with onset of SLE prior to age 18 years.

Clovis A. Silva

Tadej Avcin

Hermine I. Brunner

Arthritis Care & Research

ARTHRITIS CARE & RESEARCH 是美国风湿病学会和风湿病健康专业人员协会（学院的一个部门）的官方期刊，是一份同行评议的出版物，发表原创研究、评论文章和社论，以促进在风湿病临床实践。与风湿病患者的护理相关，主要主题是循证实践研究、临床问题、实践指南、教育、社会和公共卫生问题、卫生经济学、卫生保健政策以及风湿病实践的未来趋势。

Arthritis Care and Research is the official journal of the American College of Rheumatology and the Association of Rheumatology Health Professionals (a division of the college). This peer-reviewed publication features original research, review articles, and editorials aimed at advancing clinical practice in rheumatology. The journal primarily addresses topics related to the care of patients with rheumatic diseases, including evidence-based practice research, clinical issues, practice guidelines, education, social and public health issues, health economics, healthcare policy, and future trends in rheumatology practice.

《Arthritis Care and Research》是美国风湿病学会和风湿病健康专业人员协会（学院的一个部门）的官方期刊。这是一份经过同行评审的学术期刊，发表原创研究、评论文章和社论，旨在促进风湿病的临床实践。期刊主要关注与风湿病患者护理相关的主题，包括循证实践研究、临床问题、实践指南、教育、社会和公共卫生问题、卫生经济学、卫生保健政策以及风湿病实践的未来趋势。

Arthritis Care and Research

Arthritis Care Res

Taxonomy for systemic lupus erythematosus with onset before adulthood

To propose a common nomenclature to refer to individuals who fulfill the American College of Rheumatology classification criteria for systemic lupus erythematosus (SLE) during childhood or adolescence.

Category	Quartile
医学	2
医学, 风湿病学	3

Taxonomy for systemic lupus erythematosus with onset before adulthood

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