Maxillofacial hard tissue defects caused by trauma or infection often affect craniofacial function. Taking the natural hard tissue structure as a template, constructing an engineered tissue repair module is an important scheme to realize the functional regeneration and repair of maxillofacial hard tissue. Here, inspired by the biomineralization process, we constructed a composite mineral matrix hydrogel PAA-CMC-TDM containing amorphous calcium phosphates (ACPs), polyacrylic acid (PAA), carboxymethyl chitosan (CMC) and dentin matrix (TDM). The dynamic network composed of Ca2+·COO- coordination and ACPs made the hydrogel loaded with TDM, and exhibited self-repairing ability and injectability. The mechanical properties of PAA-CMC-TDM can be regulated, but the functional activity of TDM remains unaffected. Cytological studies and animal models of hard tissue defects show that the hydrogel can promote the odontogenesis or osteogenic differentiation of mesenchymal stem cells, adapt to irregular hard tissue defects, and promote in situ regeneration of defective tooth and bone tissues. In summary, this paper shows that the injectable TDM hydrogel based on biomimetic mineralization theory can induce hard tissue formation and promote dentin/bone regeneration.

Bo Wen

Yuguo Dai

Xue Han

Fangjun Huo

Li Xie

Mei Yu

Yuru Wang

Ning An

Zhonghan Li

Weihua Guo

npj Regenerative Medicine

NPJ REGENERATIVE MEDICINE 是一本新的开放获取、仅限在线的期刊，致力于发表最高质量的研究，以帮助人体修复、替换、恢复和再生受损组织和器官。

NPJ Regenerative Medicine is a new open-access, online-only journal dedicated to publishing high-quality research aimed at facilitating the repair, replacement, restoration, and regeneration of damaged tissues and organs in the human body.

NPJ Regenerative Medicine 是一本新的开放获取、仅限在线的期刊，专注于发表高质量的研究，旨在促进人体对受损组织和器官的修复、替换、恢复和再生。

npj Regen Med

Biomineralization-inspired mineralized hydrogel promotes the repair and regeneration of dentin/bone hard tissue

It is shown that the injectable TDM hydrogel based on biomimetic mineralization theory can induce hard tissue formation and promote dentin/bone regeneration.

Category	Quartile
医学	1
医学, 工程生物医学	1
医学, 细胞与组织工程	2

Biomineralization-inspired mineralized hydrogel promotes the repair and regeneration of dentin/bone hard tissue

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Journal Info

Category	Quartile
ENGINEERING, BIOMEDICAL	1