Abstract Myricetin derivatives containing sulfonylpiperazine were synthesized and their structures were confirmed by NMR and HRMS. The antibacterial activity results indicated that some compounds showed good antibacterial activity against Xanthomonas oryzaepv. oryzae (Xoo), Xanthomonas axonopodispv. citri (Xac) and Ralstonia solanacearum (Rs). Among them, compounds 4m and 4p revealed excellent antibacterial activities against Rs with a concentration for 50% of maximal effect (EC 50 ) value of 4 and 4 μg/mL, which were better than the control drugs bismerthiazol (13 μg/mL) and thiodiazole-copper (185 μg/mL). As observed using scanning electron microscope (SEM), these compounds act by causing folding and deformation of the bacterial surface, resulting in incomplete bacterial structure, so as to achieve the goal of bacteriostasis. The myricetin derivatives synthesized are expected to guide the research direction of new antibacterial agents.

Jun He

Xue-Mei Tang

Ting-Ting Liu

Feng Peng

Qing Zhou

Li-Wei Liu

Ming He

Wei Xue

Chemical Papers

CHEMICAL PAPERS 是一本经过同行评审的国际期刊，致力于基础和应用化学研究。它涵盖化学科学的广泛范围，但有利于将化学与其他学科结合在一起的跨学科研究和研究。

Chemical Papers is a peer-reviewed international journal dedicated to fundamental and applied research in chemistry. It covers a wide range of chemical sciences, with a particular emphasis on interdisciplinary research that integrates chemistry with other disciplines.

《Chemical Papers》是一本经过同行评审的国际期刊，专注于基础和应用化学研究。期刊涵盖化学科学的广泛领域，特别鼓励跨学科的研究，促进化学与其他学科的结合。

Category	Quartile
化学	4
化学, 化学综合	4

Synthesis and antibacterial activity of novel myricetin derivatives containing sulfonylpiperazine

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Journal Info

Category	Quartile
CHEMISTRY, MULTIDISCIPLINARY	3