Understanding and manipulating cell fate determination is pivotal in biology. Cell fate is determined by intricate and nonlinear interactions among molecules, making mathematical model-based quantitative analysis indispensable for its elucidation. Nevertheless, obtaining the essential dynamic experimental data for model development has been a significant obstacle. However, recent advancements in large-scale omics data technology are providing the necessary foundation for developing such models. Based on accumulated experimental evidence, we can postulate that cell fate is governed by a limited number of core regulatory circuits. Following this concept, we present a conceptual control framework that leverages single-cell RNA-seq data for dynamic molecular regulatory network modeling, aiming to identify and manipulate core regulatory circuits and their master regulators to drive desired cellular state transitions. We illustrate the proposed framework by applying it to the reversion of lung cancer cell states, although it is more broadly applicable to understanding and controlling a wide range of cell-fate determination processes.

Jonghoon Lee

Namhee Kim

Kwang-Hyun Cho

npj Systems Biology and Applications

NPJ SYSTEMS BIOLOGY AND APPLICATIONS 是一本在线开放获取期刊，致力于发表采用面向系统的方法的首要研究。该杂志旨在为发表有助于定义这一新兴领域的文章以及将这些进展应用于更广泛领域的文章提供一个论坛。我们鼓励整合或帮助整合从分子到生物体和更广泛系统的数据、分析和洞察力的研究。重要的关注领域不仅包括基础生物系统和药物发现，还包括在健康、医疗实践和实施、大数据、生物技术、食品科学、人类行为、更广泛的生物系统和系统生物学的工业应用中的应用。我们鼓励所有方法，包括网络生物学、控制理论在生物系统中的应用、计算建模和分析、综合和/或高内涵测量、生物系统的系统级特性的理论、分析和计算研究，以及实现此类的计算/软件/数据平台学习。

NPJ SYSTEMS BIOLOGY AND APPLICATIONS is an online open-access journal dedicated to publishing cutting-edge research that employs a systems approach. The journal aims to provide a platform for articles that contribute to defining this emerging field and for research that applies these advancements to broader domains. We encourage research that integrates or facilitates the integration of data, analyses, and insights from molecules to organisms and larger systems. Key areas of focus include not only fundamental biological systems and drug discovery but also applications in health, medical practice and implementation, big data, biotechnology, food science, human behavior, and the broader applications of systems biology in industry. We welcome all approaches, including systems biology, the application of control theory in biological systems, computational modeling and analysis, integrative and/or high-content measurement, theoretical, analytical, and computational studies of system-level characteristics of biological systems, as well as the development of computational/software/data platforms to achieve these goals.

NPJ SYSTEMS BIOLOGY AND APPLICATIONS 是一本在线开放获取期刊，专注于发表采用系统方法的前沿研究。该期刊旨在为发表有助于定义这一新兴领域的文章以及将这些进展应用于更广泛领域的研究提供一个平台。我们鼓励整合或促进从分子到生物体及更广泛系统的数据、分析和洞察力的研究。重要的关注领域不仅包括基础生物系统和药物发现，还涵盖健康、医疗实践与实施、大数据、生物技术、食品科学、人类行为以及系统生物学在工业应用中的广泛应用。我们欢迎各种研究方法，包括网络生物学、控制理论在生物系统中的应用、计算建模与分析、高内涵测量、生物系统的系统级特性理论研究，以及实现这些目标的计算/软件/数据平台的开发。

Category	Quartile
生物学	2
生物学, 数学与计算生物学	2

Decoding the principle of cell-fate determination for its reverse control

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