Evidence from epidemiological, clinical, and biological research resulted in the immune hypothesis: the hypothesis that immune system dysfunction is involved in the pathophysiology of schizophrenia spectrum disorders (SSD). The promising implication of this hypothesis is the potential to use existing immunomodulatory treatment for innovative interventions for SSD. Here, we provide a selective historical review of important discoveries that have shaped our understanding of immune dysfunction in SSD. We first explain the basic principles of immune dysfunction, after which we travel more than a century back in time. Starting our journey with neurosyphilis-associated psychosis in the nineteenth century, we continue by evaluating the role of infections and autoimmunity in SSD and findings from assessment of immune function using new techniques, such as cytokine levels, microglia density, neuroimaging, and gene expression. Drawing from these findings, we discuss anti-inflammatory interventions for SSD, and we conclude with a look into the future.

S.S. Gangadin

A.D. Enthoven

N.J.M. van Beveren

J.D. Laman

I.E.C. Sommer

Annual Review of Clinical Psychology

自 2005 年起出版的《临床心理学年度回顾》全面回顾了临床心理学和精神病学领域的重大发展。该杂志涵盖研究、理论和应用心理学原理来解决公认的疾病，包括精神分裂症、情绪、焦虑、童年、物质使用、认知和人格障碍。文章还涉及跨领域的更广泛问题，例如诊断、治疗、社会政策以及跨文化和法律问题。

The Annual Review of Clinical Psychology has been published since 2005, providing a comprehensive overview of significant developments in the fields of clinical psychology and psychiatry. This journal covers research, theory, and applied psychological principles to address recognized disorders, including schizophrenia, mood disorders, anxiety, childhood issues, substance use, cognitive disorders, and personality disorders. Articles also address broader interdisciplinary issues such as diagnosis, treatment, social policy, and cross-cultural and legal matters.

《Annual Review of Clinical Psychology》自2005年起出版，全面回顾了临床心理学和精神病学领域的重要进展。该期刊涵盖了研究、理论和应用心理学原理，以解决多种公认的心理疾病，包括精神分裂症、情绪障碍、焦虑症、儿童心理问题、物质使用障碍、认知障碍和人格障碍。文章还探讨了更广泛的跨领域问题，如诊断、治疗、社会政策以及跨文化和法律问题。

Category	Quartile
心理学	1
心理学, 心理学	1
心理学, 心理学临床	1

Immune Dysfunction in Schizophrenia Spectrum Disorders

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Journal Info

Category	Quartile
PSYCHOLOGY, CLINICAL	1