Background: Multiorgan dysfunction (MOD) is one of four consensus based criteria for the diagnosis of intrapartum asphyxia. The theoretical concept behind MOD is the diving reflex (conservation of blood flow to vital organs at the cost of non-vital organs). Objectives: To assess the patterns of involvement of each major organ/system and combinations of involvement in infants with post-asphyxial hypoxic-ischaemic encephalopathy (HIE), and to describe this in relation to long term outcome. Design: Retrospective cohort study. Setting: Regional tertiary neonatal intensive care unit at the Hospital for Sick Children, Toronto, Canada. Patients: Term neonates with post-intrapartal asphyxial HIE assessed for kidney, cardiovascular system, lung, and liver function. Outcome: Death and presence or absence of severe neurodevelopmental disability. Results: Out of 130 of 144 eligible infants with outcome data, 80 (62%) had severe adverse outcome and 50 (38%) had good outcome. All infants had evidence of MOD (at least one organ dysfunction in addition to HIE). Renal, cardiovascular, pulmonary, and hepatic dysfunction was present in 58–88% of infants with good outcome and 64–86% of infants with adverse outcome. Conclusions: MOD was present in all the infants with severe post-asphyxial HIE. However, there was no association between MOD and outcome in these infants. No relation between individual or combinations of organ involvements and long term outcomes was observed.

P Shah

Archives of Disease in Childhood - Fetal and Neonatal Edition

ARCHIVES OF DISEASE IN CHILDHOOD 是一份国际同行评审期刊，旨在让儿科医生和其他人了解儿童疾病诊断和治疗方面的最新进展，以及儿童保护等宣传问题。它侧重于从围产期（胎儿和新生儿版）到青春期的儿童健康和疾病的各个方面。 ADC 包括原始研究报告、评论、临床和政策问题评论以及证据报告。涵盖的领域包括：社区儿童健康、公共卫生、流行病学、急性儿科、宣传和伦理。

The Archives of Disease in Childhood: Fetal and Neonatal Edition is an international peer-reviewed journal aimed at keeping pediatricians and others informed about the latest advances in the diagnosis and treatment of childhood diseases, as well as issues related to child protection. The journal focuses on all aspects of child health and disease from the perinatal period (fetal and neonatal) to adolescence. It includes original research reports, reviews, discussions on clinical and policy issues, and evidence reports, covering areas such as community child health, public health, epidemiology, acute pediatrics, advocacy, and ethics.

《Archives of Disease in Childhood: Fetal and Neonatal Edition》是一本国际同行评审的学术期刊，旨在为儿科医生及其他相关人员提供儿童疾病诊断和治疗的最新进展，以及儿童保护等相关问题的宣传。期刊内容涵盖从围产期（胎儿和新生儿）到青春期的儿童健康与疾病的各个方面。期刊包括原始研究报告、评论、临床和政策问题的讨论以及证据报告，涉及的领域包括社区儿童健康、公共卫生、流行病学、急性儿科、宣传和伦理等。

Category	Quartile
医学	2
医学, 儿科	1

Multiorgan dysfunction in infants with post-asphyxial hypoxic-ischaemic encephalopathy

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