A series of indole derivatives containing quinoline structures were designed and synthesized. The synthesized compounds were characterized by NMR and HRMS. And W14 was performed by single crystal X-ray diffraction experiments. The antiviral activity studies showed that some of the target compounds possessed significant activity against tobacco mosaic virus (TMV). In particular, W20 had significant activity. The results of in vivo anti-TMV activity assay showed that W20 possessed the best curative and protective activities with EC50 values of 84.4 and 65.7 μg/mL, which were better than ningnanmycin (NNM) 205.1 and 162.0 μg/mL, respectively. The results of Microscale thermophoresis (MST) showed that W20 had a strong binding affinity for the tobacco mosaic virus coat protein (TMV-CP) with a dissociation constant (Kd) of 0.00519 μmol/L, which was superior to that of NNM (1. 65320 μmol/L). The molecular docking studies were in accordance with the experimental results. In addition, the determination of malondialdehyde (MDA) content in tobacco leaves showed that W20 improved the disease resistance of tobacco. Overall, this study shows that indole derivatives containing quinoline can be used as new antiviral agents for plant viruses for further research.

Bangcan He

Yuzhi Hu

Yishan Qin

Yufang Zhang

Xingping Luo

Zhenchao Wang

Wei Xue

Molecular diversity

MOLECULAR DIVERSITY 是一个新的出版论坛，用于快速发表专门描述分子多样性和组合化学在基础和应用研究以及药物发现中的发展、应用和理论的参考论文。该杂志发表短文和全文、观点、新闻和评论，涉及分子多样性产生的各个方面、应用多样性筛选所有类型的替代目标（生物、生物物理、技术）、分析获得的结果及其在各种科学学科/方法中的应用，包括：组合化学和平行合成；小分子库；微波合成；流动合成；氟合成；多样性导向合成 (DOS)；纳米反应器；点击化学；多重技术；基于片段和配体的设计；结构/功能/SAR；计算化学和分子设计；化学信息学；筛选技术和筛选接口；分析和纯化方法；机器人、自动化和小型化；靶向库；展示库；肽和类肽；蛋白质；寡核苷酸；碳水化合物；自然多样性;库制定和反卷积的新方法；定向进化、生命起源和重组；搜索技术、景观、随机化学等；

Molecular Diversity is a new publishing forum aimed at the rapid dissemination of reference papers that describe the developments, applications, and theories of molecular diversity and combinatorial chemistry in fundamental and applied research, as well as drug discovery. The journal publishes short articles, full papers, viewpoints, news, and reviews covering all aspects of molecular diversity generation and application diversity screening of various alternative targets (biological, biophysical, technological). Topics include: combinatorial chemistry and parallel synthesis, small molecule libraries, microwave synthesis, flow synthesis, fluorine synthesis, diversity-oriented synthesis (DOS), nanoreactors, click chemistry, multiplex technologies, fragment- and ligand-based design, structure/function/SAR, computational chemistry and molecular design, cheminformatics, screening technologies and interfaces, analytical and purification methods, robotics, automation and miniaturization, targeted libraries, display libraries, peptides and peptoids, proteins, oligonucleotides, carbohydrates, natural diversity, new methods for library design and deconvolution, directed evolution, origin of life and recombination, search technologies, landscapes, random chemistry, etc.

《Molecular Diversity》是一个新的出版论坛，旨在快速发表关于分子多样性和组合化学在基础研究、应用研究及药物发现中的发展、应用和理论的参考论文。该杂志发表短文、全文、观点、新闻和评论，涵盖分子多样性产生的各个方面，以及应用多样性筛选所有类型的替代目标（生物、生物物理、技术）。内容包括：组合化学和平行合成、小分子库、微波合成、流动合成、氟合成、多样性导向合成（DOS）、纳米反应器、点击化学、多重技术、基于片段和配体的设计、结构/功能/SAR、计算化学和分子设计、化学信息学、筛选技术和筛选接口、分析和纯化方法、机器人、自动化和小型化、靶向库、展示库、肽和类肽、蛋白质、寡核苷酸、碳水化合物、自然多样性、库制定和反卷积的新方法、定向进化、生命起源和重组、搜索技术、景观、随机化学等。

Molecular Diversity

Mol Divers

Design, synthesis and antiviral activity of indole derivatives containing quinoline moiety.

Indole derivatives containing quinoline can be used as new antiviral agents for plant viruses for further research and shows that W20 improved the disease resistance of tobacco.

Category	Quartile
化学	2
化学, 应用化学	3
化学, 药物化学	3
化学, 化学综合	3

Design, synthesis and antiviral activity of indole derivatives containing quinoline moiety.

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Journal Info

Category	Quartile
CHEMISTRY, MULTIDISCIPLINARY	2