Ocean metabolism constitutes a complex, multiscale ensemble of biochemical reaction networks harbored within and between the boundaries of a myriad of organisms. Gaining a quantitative understanding of how these networks operate requires mathematical tools capable of solving in silico the resource allocation problem each cell faces in real life. Toward this goal, stoichiometric modeling of metabolism, such as flux balance analysis, has emerged as a powerful computational tool for unraveling the intricacies of metabolic processes in microbes, microbial communities, and multicellular organisms. Here, we provide an overview of this approach and its applications, future prospects, and practical considerations in the context of marine sciences. We explore how flux balance analysis has been employed to study marine organisms, help elucidate nutrient cycling, and predict metabolic capabilities within diverse marine environments, and highlight future prospects for this field in advancing our knowledge of marine ecosystems and their sustainability.

Helen Scott

Daniel Segrè

Annual Review of Marine Science

自 2009 年起出版的《海洋科学年度回顾》提供了关于海洋科学领域的观点。该杂志从沿海和蓝水海洋学（生物、化学、地质和物理）的主要学科以及以海洋环境为统一主题的生态学、保护和技术发展学科的不同主题中汲取灵感。

The Annual Review of Marine Science, published since 2009, offers in-depth perspectives on the field of marine science. This journal draws inspiration from major disciplines of coastal and blue water oceanography, including biology, chemistry, geology, and physics, as well as various topics related to ecology, conservation, and technological developments centered around the marine environment.

《Annual Review of Marine Science》自2009年起出版，提供了关于海洋科学领域的深入观点。该期刊涵盖了沿海和深海海洋学的主要学科，包括生物、化学、地质和物理等方面，同时也探讨了以海洋环境为主题的生态学、保护和技术发展的不同领域。

Category	Quartile
地球科学	1
地球科学, 地球化学与地球物理	1
地球科学, 海洋与淡水生物学	1
地球科学, 海洋学	1

Metabolic Flux Modeling in Marine Ecosystems

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