The purpose of this paper is to summarize the blood purification technology applied in patients with severe fever with thrombocytopenia syndrome (SFTS) in the clinical treatment effect.The medical records of 96 patients with severe SFTS admitted to Weihai Municipal Hospital affiliated to Shandong University from May 2014 to November 2019 were retrospectively analyzed, and they were divided into survival group and death group. The differences in basic data test indexes and treatment method selection during intensive care unit (ICU) admission between the two groups were significantly analyzed, and the indexes with statistically significant differences were included in the multivariate logistic regression analysis related to prognosis.There were no statistically significant differences in age, sex composition, white blood cell count, platelet count, creatine kinase (CK), activated partial thromboplastin time (APTT), serum creatinine and hemofiltration renal replacement therapy between the survival group and the death group. There were statistically significant differences between the two groups in viral load bilirubin and the treatment methods of plasma exchange (PE) or hemoperfusion (HP). Plasma exchange group (78 cases), hemofiltration group (12 cases), hemoperfusion group (6 cases), plasma exchange and hemoperfusion and other blood purification treatment of the prognosis were statistically different.Compared with the three blood purification methods, plasmapheresis has a significant effect on virus removal, improvement of coagulation function and survival rate in patients with severe SFTS. Hemofiltration plays a role in removing inflammatory mediators, replacing renal function, maintaining electrolytes and acid-base balance, but not in removing viruses.

Hongxia Gao

Baoyin Wang

Hui Yao

Wenjie Zhang

HaiFeng Teng

Biotechnology and Genetic Engineering Reviews

《生物技术与基因工程评论》发表主要受邀评论文章，涵盖生物技术在工业、农业和医学应用方面的重要发展。

Biotechnology and Genetic Engineering Reviews primarily publishes invited review articles that cover significant advancements in the applications of biotechnology in industry, agriculture, and medicine.

《生物技术与基因工程评论》主要发表受邀的评论文章，涵盖生物技术在工业、农业和医学应用方面的重要进展。

Category	Quartile
工程技术	3
工程技术, 生物工程与应用微生物	4
工程技术, 遗传学	4

Application of blood purification technology in severe fever with thrombocytopenia syndrome

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Category	Quartile
GENETICS & HEREDITY	1