In Brief Growth substances (cytokines and growth factors) are soluble signaling proteins affecting the process of normal wound healing. Cytokines govern the inflammatory phase that clears cellular and extracellular matrix debris. Wound repair is controlled by growth factors (platelet-derived growth factor [PDGF], keratinocyte growth factor, and transforming growth factor β). Endogenous growth factors communicate across the dermal-epidermal interface. PDGF is important for most phases of wound healing. Becaplermin (PDGF-BB), the only growth factor approved by the Food and Drug Administration, requires daily application for neuropathic wound healing. Gene therapy is under development for more efficient growth factor delivery; a single application will induce constitutive growth factor expression for weeks. Based on dramatic preclinical animal studies, a phase 1 clinical trial planned on a PDGF genetic construct appears promising. Despite a slow start, growth factors have great therapeutic potential for chronic wounds. This literature review examines notable preclinical and clinical trials of topically applied growth factors and looks at the impact gene therapy could have.

Robert Goldman

Advances in Skin & Wound Care

A peer-reviewed, multidisciplinary journal, Advances in Skin & Wound Care is highly regarded for its unique balance of cutting-edge original research and practical clinical management articles on wounds and other problems of skin integrity. Each issue features CME/CE for physicians and nurses, the first journal in the field to regularly offer continuing education for both disciplines.

Advances in Skin and Wound Care is a peer-reviewed, multidisciplinary journal that is highly regarded for its unique balance of cutting-edge original research and practical clinical management articles on wounds and other issues related to skin integrity. Each issue features CME/CE for physicians and nurses, making it the first journal in the field to regularly offer continuing education for both disciplines.

《Advances in Skin and Wound Care》是一本经过同行评审的多学科期刊，以其在伤口及皮肤完整性问题上独特的前沿原创研究和实用临床管理文章而受到高度评价。每期都为医生和护士提供继续医学教育（CME/CE），是该领域首个定期为这两个学科提供继续教育的期刊。

Advances in Skin and Wound Care

Growth Factors and Chronic Wound Healing: Past, Present, and Future

Based on dramatic preclinical animal studies, a phase 1 clinical trial planned on a PDGF genetic construct appears promising, and a single application will induce constitutive growth factor expression for weeks.

Category	Quartile
医学	4
医学, 皮肤病学	3
医学, 护理	3
医学, 外科	4

Growth Factors and Chronic Wound Healing: Past, Present, and Future

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