Abstract The impact of human IgE glycosylation on structure, function and disease mechanisms is not fully elucidated, and heterogeneity in different studies renders drawing conclusions challenging. Previous reviews discussed IgE glycosylation focusing on specific topics such as health versus disease, FcεR binding or impact on function. We present the first systematic review of human IgE glycosylation conducted utilizing the PRISMA guidelines. We sought to define the current consensus concerning the roles of glycosylation on structure, biology and disease. Despite diverse analytical methodologies, source, expression systems and the sparsity of data on IgE antibodies from non‐allergic individuals, collectively evidence suggests differential glycosylation profiles, particularly in allergic diseases compared with healthy states, and indicates functional impact, and contributions to IgE‐mediated hypersensitivities and atopic diseases. Beyond allergic diseases, dysregulated terminal glycan structures, including sialic acid, may regulate IgE metabolism. Glycan sites such as N394 may contribute to stabilizing IgE structure, with alterations in these glycans likely influencing both structure and IgE‐FcεR interactions. This systematic review therefore highlights critical IgE glycosylation attributes in health and disease that may be exploitable for therapeutic intervention, and the need for novel analytics to explore pertinent research avenues.

Alexandra J. McCraw

Lais C. G. F. Palhares

Jenifer L. Hendel

Richard A. Gardner

Aida Santaolalla

Silvia Crescioli

James McDonnell

Mieke Van Hemelrijck

Alicia Chenoweth

Daniel I. R. Spencer

Gerd K. Wagner

Sophia N. Karagiannis

Allergy

ALLERGY 的目的是推进、影响和交流过敏/免疫学学科的各个方面，包括教育、基础、转化和临床研究，并保持基础和临床过敏/免疫学之间的联系。ALLERGY 是一本国际期刊，其贡献者和读者来自所有国家。 ALLERGY 发表原创文章、评论、立场文件、指南、社论、新闻和评论、致编辑的信函和通信。文章的接受纯粹是基于科学价值和质量。

The purpose of Allergy: European Journal of Allergy and Clinical Immunology is to advance, influence, and communicate all aspects of the field of allergy and immunology, including education, basic research, translational research, and clinical studies, while maintaining a close connection between basic and clinical allergy/immunology. This is an international journal with contributors and readers from all countries. Allergy publishes original research articles, reviews, position papers, guidelines, editorials, news, letters to the editor, and communications. Acceptance of articles is solely based on their scientific value and quality.

《Allergy: European Journal of Allergy and Clinical Immunology》旨在推动、影响和交流过敏与免疫学领域的各个方面，包括教育、基础研究、转化研究和临床研究，并保持基础与临床过敏/免疫学之间的紧密联系。该期刊是一本国际性期刊，贡献者和读者来自世界各地。《Allergy》发表原创研究文章、评论、立场文件、指南、社论、新闻、读者来信及其他通讯。文章的接受完全基于其科学价值和质量。

Allergy: European Journal of Allergy and Clinical Immunology

<scp>I</scp>g<scp>E</scp> glycosylation and impact on structure and function: A systematic review

IgE糖基化及其对结构和功能的影响：一项系统综述

Category	Quartile
医学	1
医学, 免疫学	1
医学, 过敏	2

IgE glycosylation and impact on structure and function: A systematic review

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