Abstract Severe acute pancreatitis (SAP) is characterized by acute inflammation of the pancreas. The transcription factor BTB and CNC homology 1 (BACH1) has been implicated in various biological processes, including oxidative stress, apoptosis, and cell cycle regulation. However, its involvement in the pathogenesis of SAP remains relatively understudied. In the present work, our data demonstrated that BACH1 level was significantly increased in SAP patients, cellular, and animal models, while heat shock protein B1 (HSPB1) expression was weakened. Mechanistic assays validated that BACH1 acted as a transcriptional inhibitor of HSPB1. Moreover, HPDE6‐C7 cells were stimulated with cerulein (Cer) and LPS to mimic the pathological stages of SAP in vitro. Depletion of BACH1 remarkably improved cell survival and alleviated the oxidative stress, ferroptosis, and inflammatory responses in SAP cell models. However, these changes were dramatically reversed upon co‐inhibition of HSPB1. Animal findings confirmed that loss of BACH1 decreased pancreatic injury, inflammatory responses, and ferroptosis, but these effects were weakened by HSPB1 silence. Overall, these findings elucidate that the overexpression of BACH1 favors the ferroptosis and inflammation by transcriptionally inhibiting HSBP1, thereby exacerbating SAP progression.

Fawei Zhou

Dezhong Li

Chang Liu

Can Li

Kaili Li

Lu Shi

Fachun Zhou

Drug Development Research

药物开发研究侧重于与新治疗实体的发现和开发相关的研究课题。该杂志发表关于药物化学、药理学、生物技术和生物制药、毒理学和药物输送、配方和药代动力学的原创研究文章。该杂志欢迎所有领域的新化合物和技术的手稿，重点关注人类治疗，以及涉及药物发现和开发过程的全球管理、医疗保健政策和监管问题。除长篇文章外，药物开发研究部还发布有关重要且及时的新研究发现的简要报告，以及深入的评论文章。该杂志还定期发表专门针对特定化合物类别、新技术以及药物发现和开发的广泛方面的专题。

Drug Development Research focuses on research topics related to the discovery and development of new therapeutic entities. The journal publishes original research articles on drug chemistry, pharmacology, biotechnology and biopharmaceuticals, toxicology, as well as drug delivery, formulation, and pharmacokinetics. We welcome manuscripts on new compounds and technologies from all fields, with a particular emphasis on human therapeutics and global management, healthcare policy, and regulatory issues related to the drug discovery and development process. In addition to full-length research articles, Drug Development Research also publishes brief reports on significant and timely new research findings, as well as in-depth review articles. The journal regularly features special topics that focus on specific classes of compounds, new technologies, and the broad aspects of drug discovery and development.

《Drug Development Research》专注于与新治疗实体的发现和开发相关的研究课题。该杂志发表关于药物化学、药理学、生物技术和生物制药、毒理学以及药物输送、配方和药代动力学的原创研究文章。我们欢迎所有领域的新化合物和技术的手稿，特别关注人类治疗，以及涉及药物发现和开发过程的全球管理、医疗保健政策和监管问题。除了长篇研究文章外，《Drug Development Research》还发布关于重要且及时的新研究发现的简要报告，以及深入的评论文章。该杂志定期发表专门针对特定化合物类别、新技术以及药物发现和开发的广泛方面的专题。

Category	Quartile
医学	4
医学, 药物化学	3
医学, 药学	4

m6A‐activated BACH1 exacerbates ferroptosis by epigenetic suppression HSPB1 in severe acute pancreatitis

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Journal Info

Category	Quartile
PHARMACOLOGY & PHARMACY	2