There are currently 5 botulinumtoxin-a products approved for cosmetic use in the United States: onabotulinumtoxin-a, abobotulinumtoxin-a, incobotulinumtoxin-a, prabotulinumtoxin-a, and daxibotulinumtoxin-a. New neuromodulators are destined for the market place soon including a serotype E and 2 additional serotype A botulinumtoxins. Optimizing esthetic use of neuromodulators relies on an intimate knowledge of anatomy . By altering one's injection technique, the risk of brow ptosis can be minimized. Neuromodulators can contribute to lifting of the upper face and minimizing infraorbital hallows when injected strategically in the lower face. Contouring off-face musculature has become popular.

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