During exercise, there is a progressive reduction in the ability to produce muscle force. Processes within the nervous system as well as within the muscles contribute to this fatigue. In addition to impaired function of the motor system, sensations associated with fatigue and impairment of homeostasis can contribute to the impairment of performance during exercise. This review discusses some of the neural changes that accompany exercise and the development of fatigue. The role of brain monoaminergic neurotransmitter systems in whole-body endurance performance is discussed, particularly with regard to exercise in hot environments. Next, fatigue-related alterations in the neuromuscular pathway are discussed in terms of changes in motor unit firing, motoneuron excitability, and motor cortical excitability. These changes have mostly been investigated during single-limb isometric contractions. Finally, the small-diameter muscle afferents that increase firing with exercise and fatigue are discussed. These afferents have roles in cardiovascular and respiratory responses to exercise, and in the impairment of exercise performance through interaction with the motor pathway, as well as in providing sensations of muscle discomfort. Thus, changes at all levels of the nervous system, including the brain, spinal cord, motor output, sensory input, and autonomic function, occur during exercise and fatigue. The mix of influences and the importance of their contribution vary with the type of exercise being performed.

JANET L. TAYLOR

MARKUS AMANN

JACQUES DUCHATEAU

ROMAIN MEEUSEN

CHARLES L. RICE

Medicine & Science in Sports & Exercise

Medicine & Science in Sports & Exercise® features original investigations, clinical studies, and comprehensive reviews on current topics in sports medicine and exercise science. With this leading multidisciplinary journal, exercise physiologists, physiatrists, physical therapists, team physicians, and athletic trainers get a vital exchange of information from basic and applied science, medicine, education, and allied health fields.

Medicine & Science in Sports & Exercise® is a leading multidisciplinary journal that publishes original investigations, clinical studies, and comprehensive reviews on current topics in sports medicine and exercise science. This journal serves as a vital platform for exercise physiologists, physiatrists, physical therapists, team physicians, and athletic trainers to exchange information across basic and applied sciences, medicine, education, and allied health fields.

《Medicine and Science in Sports and Exercise》是一本涵盖运动医学和运动科学领域的多学科领先期刊，发表原创研究、临床研究和关于当前主题的综合评述。该期刊为运动生理学家、康复医学专家、物理治疗师、团队医生和运动训练师提供了一个重要的信息交流平台，涉及基础与应用科学、医学、教育及相关健康领域。

Category	Quartile
医学	2
医学, 运动科学	2

Neural Contributions to Muscle Fatigue

ivySCI AI Smartly Parses PDF, Answers Researchers' Questions, and Helps You Understand Papers in Seconds

Journal Info

Category	Quartile
SPORT SCIENCES	1