Much of the current research in regenerative medicine concentrates on stem-cell therapy that exploits the regenerative capacities of stem cells when injected into different types of human tissues. Although new therapeutic paths have been opened up by induced pluripotent cells and human mesenchymal cells, the rate of success is still low and mainly due to the difficulties of managing cell proliferation and differentiation, giving rise to non-controlled stem cell differentiation that ultimately leads to cancer. Despite being still far from becoming a reality, these studies highlight the role of physical and biological constraints (e.g., cues and morphogenetic fields) placed by tissue microenvironment on stem cell fate. This asks for a clarification of the coupling of stem cells and microenvironmental factors in regenerative medicine. We argue that extracellular matrix and stem cells have a causal reciprocal and asymmetric relationship in that the 3D organization and composition of the extracellular matrix establish a spatial, temporal, and mechanical control over the fate of stem cells, which enable them to interact and control (as well as be controlled by) the cellular components and soluble factors of microenvironment. Such an account clarifies the notions of stemness and stem cell regeneration consistently with that of microenvironment.

Guglielmo Militello

Marta Bertolaso

Acta Biotheoretica

ACTA BIOTHEORETICA 致力于推动理论生物学，涵盖数学生物学和生物学哲学，特别关注生物学理论形成的方法学。欢迎各种生物学理论的论文。有趣的科目包括生物学哲学、生物数学、计算生物学、遗传学、生态学和形态学。理论形成的过程可以用语言或数学的形式呈现。此外，纯方法论论文可以致力于生物学理论和概念背后的哲学的历史渊源。论文应包含对生物学假设的清晰陈述，并在适用的情况下，将其翻译成数学形式的理由以及对数学处理的详细讨论.应澄清与经验数据的联系。ACTA BIOTHEORETICA 还欢迎批评性书评、对先前论文的简短评论以及将注意力集中在有趣的新理论思想上的简短笔记。

Acta Biotheoretica is dedicated to advancing the field of theoretical biology, encompassing mathematical biology and the philosophy of biology, with a particular focus on the methodologies of theory formation in biology. We welcome papers on a variety of biological theories, with interesting topics including the philosophy of biology, biomathematics, computational biology, genetics, ecology, and morphology. The process of theory formation can be presented in either linguistic or mathematical forms. Additionally, purely methodological papers may delve into the historical origins of the philosophy behind biological theories and concepts. Papers should include a clear statement of biological hypotheses and, where applicable, provide justifications for translating these into mathematical forms, along with detailed discussions of the mathematical treatment. The connection to empirical data should also be clarified. Acta Biotheoretica also welcomes critical book reviews, brief comments on previous papers, and short notes focusing on intriguing new theoretical ideas.

《Acta Biotheoretica》致力于推动理论生物学的研究，涵盖数学生物学和生物学哲学，特别关注生物学理论形成的方法论。我们欢迎各种生物学理论的论文，感兴趣的主题包括生物学哲学、生物数学、计算生物学、遗传学、生态学和形态学。理论形成的过程可以通过语言或数学的形式呈现。此外，纯方法论的论文也可以探讨生物学理论和概念背后的哲学历史渊源。论文应包含对生物学假设的清晰陈述，并在适用的情况下，提供将其翻译成数学形式的理由以及对数学处理的详细讨论。同时，应明确与经验数据的联系。《Acta Biotheoretica》还欢迎批评性书评、对先前论文的简短评论，以及关注有趣的新理论思想的简短笔记。

Category	Quartile
生物学	4
生物学, 数学与计算生物学	4

Stem Cells and the Microenvironment: Reciprocity with Asymmetry in Regenerative Medicine

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Category	Quartile
MATHEMATICAL & COMPUTATIONAL BIOLOGY	4