This study investigated the association between the basal (rest) insulin-signaling proteins, Akt, and the Akt substrate AS160, metabolic risk factors, inflammatory markers and aerobic fitness, in middle-aged women with varying numbers of metabolic risk factors for type 2 diabetes.Sixteen women (n=16) aged 51.3 +/- 5.1 (mean +/- SD) years provided muscle biopsies and blood samples at rest. In addition, anthropometric characteristics and aerobic power were assessed and the number of metabolic risk factors for each participant was determined (IDF criteria).The mean number of metabolic risk factors was 1.6 +/- 1.2. Total Akt was negatively correlated with IL-1beta (r = -0.45, p = 0.046), IL-6 (r = -0.44, p = 0.052) and TNF-alpha (r = -0.51, p = 0.025). Phosphorylated AS160 was positively correlated with HDL (r = 0.58, p = 0.024) and aerobic fitness (r = 0.51, p = 0.047). Furthermore, a multiple regression analysis revealed that both HDL (t = 2.5, p = 0.032) and VO2peak (t = 2.4, p = 0.037) were better predictors for phosphorylated AS160 than TNF-alpha or IL-6 (p > 0.05).Elevated inflammatory markers and increased metabolic risk factors may inhibit insulin-signaling protein phosphorylation in middle-aged women, thereby increasing insulin resistance under basal conditions. Furthermore, higher HDL and fitness levels are associated with an increased AS160 phosphorylation, which may in turn reduce insulin resistance.

Itamar Levinger

Kirsten F Howlett

Jonathan Peake

Andrew Garnham

David L Hare

George Jerums

Steve Selig

Craig Goodman

Exercise immunology review

运动免疫学评论 (EIR) 是国际运动与免疫学学会和德国运动医学与预防学会的官方出版物。它致力于发展和丰富与急性运动和定期体育活动相关的免疫学各个方面的知识。 EIR 发表评论文章和具有新的原始数据的论文，包括扩展的、类似评论的讨论。鉴于有助于理解免疫功能的广泛学科，该杂志采用了跨学科重点。这允许传播来自运动科学、医学、免疫学、生理学、行为科学、内分泌学、药理学和心理学等学科的研究成果。

Exercise Immunology Review is the official publication of the International Society of Exercise and Immunology and the German Society of Sports Medicine and Prevention. It is dedicated to advancing and enriching knowledge related to immunology in the context of acute exercise and regular physical activity. The journal publishes review articles and original research papers with new data, including extended discussions similar to reviews. Given the broad disciplines that contribute to understanding immune function, the journal adopts an interdisciplinary focus, allowing for the dissemination of research findings from fields such as exercise science, medicine, immunology, physiology, behavioral science, endocrinology, pharmacology, and psychology.

《Exercise Immunology Review》是国际运动与免疫学学会和德国运动医学与预防学会的官方出版物，致力于发展和丰富与急性运动和定期体育活动相关的免疫学知识。该期刊发表评论文章和包含新原始数据的研究论文，内容涵盖广泛的学科，以帮助理解免疫功能。期刊采用跨学科的重点，传播来自运动科学、医学、免疫学、生理学、行为科学、内分泌学、药理学和心理学等领域的研究成果。

Category	Quartile
医学	4
医学, 免疫学	4
医学, 运动科学	4

Akt, AS160, metabolic risk factors and aerobic fitness in middle-aged women.

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Journal Info

Category	Quartile
SPORT SCIENCES	1