Background. Ischemic stroke is the leading cause of mortality and loss of working ability. Sleep disorders and sleep-wake rhythm disorders are considered to be a potential modifiable risk factor of acute stroke. Objective. To determine the peculiarities of circadian rhythms in acute stroke by assessing the daily variation of urinary excretion of cortisol and 6-sulfatoxymelatonin. Materials and methods. We examined 27 patients with acute ischemic stroke and 9 patients admitted to the hospital with suspected but not confirmed stroke. All examinations in both groups were performed in similar settings. All patients underwent neurological assessment in acute phase and before discharge including evaluation by National Institute of Health Stroke Scale, modified Rankin scale (mRs), Barthel index and Rivermead index. Within 48–72 hours after admission, urine samples were collected at 7 a. m., 3 p. m. and 11 p. m. for cortisol and 6-sulfatoxymelatonin assessment (enzyme-linked immunosorbent assay analysis). Results. Daily urinary cortisol excretion did not differ in stroke and control subjects. However, stroke patients demonstrated the highest values in the evening while control subjects had higher levels in the morning. The rhythm of urinary 6-sulfatoxymelatonin excretion is preserved in both groups with the highest level in the morning. However, stroke patients show lower levels at all time points (by 45 %, 33 % and 72 % in the morning, afternoon and evening, respectively). There were no changes in either cortisol or 6-sulfatoxymelatonin excretion depending on stroke severity. Afternoon excretion of 6-sulfatoxymelatonin correlates with Barthel index at discharge (ρ = 0,63; p = 0,004), mRs score at discharge (ρ = –0,65; p = 0,003) and Rivermead index at admission (ρ = 0,52; p = 0,024) and at discharge (ρ = 0,49; p = 0,032). Conclusion. Patients with acute mild-moderate stroke show abnormal daily rhythm of urinary cortisol excretion with the maximum in the evening. The daily rhythm of 6-sulfatoxymelatonin excretion is preserved with the maximum excretion at night, but stroke patients have lower levels compared to control subjects.

L. S. Korostovtseva

E. N. Zabroda

S. N. Kolomeychuk

A. D. Gordeev

V. V. Amelina

E. A. Stabrova

E. Y. Vasilieva

M. V. Bochkarev

Y. V. Sviryaev

Arterial’naya Gipertenziya (Arterial Hypertension)

The main aims of the Journal include collecting and generalizing the knowledge in hypertensiology; education and professional development of cardiologists and medical doctors of other specialties, who deal with different issues regarding diagnostics, management and prevention of hypertension in both clinical practice and research. The Journal also calls attention to the most urgent and up-to-date questions in hypertensiology, cardiology and related sciences. There are additional objectives, such as increasing the availability, accessibility and recognition of Russian medical scientific achievements at the international level by improving the quality of the publication and the way they are presented; enabling the exchange of opinions and information between scientists and their wider communication.    The main criteria for publication selection fit with the mentioned objectives and include currency, singularity, scientific and practical novelty, applied relevance etc.

The main aims of the journal "Arterial Hypertension (Russian Federation)" include collecting and generalizing knowledge in the field of hypertensiology, as well as promoting the education and professional development of cardiologists and medical doctors from other specialties who deal with various issues related to the diagnosis, management, and prevention of hypertension in both clinical practice and research. The journal also addresses the most urgent and contemporary questions in hypertensiology, cardiology, and related sciences. Additional objectives include increasing the availability, accessibility, and recognition of Russian medical scientific achievements at the international level by improving the quality of publications and their presentation; facilitating the exchange of opinions and information among scientists and enhancing their communication. The main criteria for publication selection align with these objectives and include currency, uniqueness, scientific and practical novelty, and applied relevance.

《Arterial Hypertension (Russian Federation)》期刊的主要目标是收集和总结高血压学领域的知识，促进心脏病学及其他相关专业医生的教育和职业发展，帮助他们处理与高血压的诊断、管理和预防相关的各种问题，无论是在临床实践还是研究中。期刊还关注高血压学、心脏病学及相关科学领域中最紧迫和最新的问题。除此之外，期刊的其他目标包括提高俄罗斯医学科学成就的国际可及性和认可度，通过提升出版质量和展示方式来实现；促进科学家之间的意见和信息交流，增强他们的沟通。期刊的出版选择标准与上述目标相符，包括时效性、独特性、科学和实践的新颖性、应用相关性等。

Molecular circadian markers in acute ischemic stroke (preliminary results)

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