The importance of those remarkable cytological units, the tissue mast cells, has soared in recent years. This paper reviews briefly some of the newer concepts of these cells and reports on the author's experience with histological techniques for the study of mast cell acid polysaccharides in the cutaneous lesions of urticaria pigmentosa. Some Newer Concepts of Tissue Mast Cells Although the distribution of mast cells varies from species to species, their characteristic location in warm-blooded vertebrates is the loose fibrillary tissue which surrounds small blood vessels and underlies epithelial, serous and synovial membranes.<sup>1,13</sup>In general, parenchymatous organs are poor in mast cells, a noteworthy exception being the widespread distribution of mast cells throughout the parenchyma of the dog's liver.<sup>1</sup>Urticaria pigmentosa, the lesions of which are featured by agglomerations of mast cells, has been known for many years. Only recently, however,

The Remarkable Tissue Mast Cells

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