Background: Obesity along with hypertension is the common risk factor for the development of cardiovascular disease. Leptin, an anti-obesity hormone, is currently considered to play a vital role in the development of hypertension in obesity. We aim to determine the leptin levels in hypertensive and normotensive participants and to find the correlation between leptin and hypertension in obese and non-obese hypertensive subjects. Material and methods: A total of 94 participants aged &gt; 18years of either gender were included in the study. The participants were divided into obese (n = 55) and non-obese (n = 39) groups with further subgroups based on presence or absence of hypertension. Height, weight and blood pressure were taken with standard methods. Leptin was determined using ELISA method and intra and inter-group comparisons were made. Results: The leptin levels were significantly higher in obese (p = 0.000), hypertensive (p = 0.048) and females (p = 0.001) compared to non-obese, normotensive and male participants. Furthermore, obese hypertensive participants were having higher leptin levels compared to obese normotensive participants but with no statistical significance (p = 0.14). Serum leptin levels positively correlated with serum LDL (p = 0.003), body mass index (BMI) (p = 0.000), serum uric acid (p = 0.034) and fasting plasma glucose (FPG) (p = 0.001). However, on correction for factors like BMI, and obesity, positive correlation persisted only for female gender (p = 0.048) and FPG (p = 0.029). Furthermore, BMI (p = 0.021) and FPG (p = 0.027) were found to be the independent risk factors for elevated leptin levels on multiple regression analysis. Conclusions: Our study concluded that serum leptin levels are higher in obesity and have a direct correlation with degree of obesity. However, our study does not support any direct correlation between serum leptin and hypertension.

Hilal Bhat

Javaid Ahmad Bhat

Moomin Hussain Bhat

Masrat Rashid

Rafi Jan

Dil Afroze

Arterial Hypertension

Arterial Hypertension hereinafter referred to as ‘AH’ or ′the Journal′, is a peer-reviewed, open access journal covering broad spectrum of topics in hypertension and aiming to advance the knowledge and science of this constantly evolving field. The Journal is the official quarterly of the Polish Society of Hypertension and publishes review articles, original clinical and experimental investigations in the field of arterial hypertension, case reports, letters and editorial comments. The Journal's content has been published predominantly in full text English since 2015.

Arterial Hypertension, hereinafter referred to as 'AH' or 'the Journal', is a peer-reviewed, open access journal that covers a wide range of topics in the field of hypertension, aiming to advance knowledge and science in this constantly evolving area. The Journal is the official quarterly publication of the Polish Society of Hypertension and publishes review articles, original clinical and experimental investigations, case reports, letters, and editorial comments. Since 2015, the Journal's content has predominantly been published in full text in English.

《Arterial Hypertension》是一本经过同行评审的开放获取期刊，涵盖高血压领域的广泛主题，旨在推动这一不断发展的领域的知识和科学进步。该期刊是波兰高血压学会的官方季刊，发表高血压领域的综述文章、原创临床和实验研究、病例报告、信件及编辑评论。自2015年以来，期刊的内容主要以英文全文形式发布。

Leptin in obesity and hypertension

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Journal Info

Category	Quartile
PERIPHERAL VASCULAR DISEASE	4