Purpose: From the myofibrils to the whole muscle scale, muscle micro-constituents exhibit passive and active mechanical properties, potentially coupled to electrical, chemical, and thermal properties. Experimental characterization of some of these properties is currently not available for all muscle constituents. Multiscale multiphysics models have recently gained interest as a numerical alternative to investigate the healthy and diseased physiological behavior of the skeletal muscle. Methods: This paper refers to the multiscale mechanical models proposed in the literature to investigate the mechanical properties and behavior of skeletal muscles. More specifically, we focus on the scale transition methods, constitutive laws and experimental data implemented in these models. Results: Using scale transition methods such as homogenization, coupled to appropriate constitutive behavior of the constituents, these models explore the mechanisms of ageing, myopathies, sportive injuries, and muscle contraction. Conclusion: Emerging trends include the development of multiphysics simulations and the coupling of modeling with the acquisition of experimental data at different scales, with increasing focus to little known constituents such as the extracellular matrix and the protein titin.

Aude Loumeaud

Philippe Pouletaut

Sabine Bensamoun

Daniel George

Simon Chatelin

Journal of Medical and Biological Engineering

JMBE医学与生物工程杂志的宗旨是致力于鼓励和提供生物医学工程的标准。该刊致力于发表临床工程、生物医学信号、医学影像、生物信息学、组织工程等领域的论文。除上述文章外，还包括任何有助于达到目的的热点问题和技术发展的贡献。

The Journal of Medical and Biological Engineering aims to encourage and promote the standardization of biomedical engineering. This journal focuses on publishing research papers in the fields of clinical engineering, biomedical signal processing, medical imaging, bioinformatics, and tissue engineering. Additionally, it welcomes contributions on any hot topics and technological developments that help achieve these objectives.

《Journal of Medical and Biological Engineering》旨在鼓励和推动生物医学工程领域的标准化发展。该期刊专注于发表临床工程、生物医学信号处理、医学影像学、生物信息学、组织工程等相关领域的研究论文。此外，期刊还欢迎任何有助于实现这些目标的热点问题和技术发展的贡献。

Category	Quartile
医学	4
医学, 工程生物医学	4

Multiscale Mechanical Modeling of Skeletal Muscle: A Systemic Review of the Literature

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Journal Info

Category	Quartile
ENGINEERING, BIOMEDICAL	4