ABSTRACT Sixty-four patients over the age of 40 years, undergoing elective surgery of at least one hour's duration, were randomized to treatment with either a thromboembolic deterrent (TED) stocking (Kendall Co.) or subcutaneous low-dose heparin 5000 IU every 12 hours. Serum levels of alanine aminotransferase (S-ALAT), aspartate aminotransferase (SASAT), γ-glutamyl transpeptidase (S-γ-GT) and alkaline phosphatase (S-ALP) were measured. S-ALAT increased significantly on the 5th and 10th postoperative day, from 27±2 (x̄±SE) to 40±4 (p<0.01) and 55±7 U/1 (p<0.001), respectively, in the heparin group and was significantly higher in the heparin than in the TED group both on the 5th (p<0.01) and 10th (p<0.05) postoperative day. S-ASAT and S-γ-GT increased significantly during heparin treatment, but did not differ significantly from the values of the TED group. No change in S-ALP was registered in either group. It is concluded that prophylactic treatment with low-dose heparin induces a significant increase in S-aminotransferase levels, especially in S-ALAT. The phenomenon has profound differential diagnostic implications in conditions such as pulmonary embolism and acute myocardial infarction.

HANS KRAEMMER NIELSEN

STEEN ELKJAER HUSTED

HANS DIETER KOOPMANN

HELGE FASTING

OLE SIMONSEN

KJELD ANDERSEN

HANS CHRISTIAN HUSEGAARD

TOM KRINTEL PETERSEN

Acta Medica Scandinavica

Heparin-Induced Increase in Serum Levels of Aminotransferases

肝素诱导的血清转氨酶水平升高

Heparin-Induced Increase in Serum Levels of Aminotransferases

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