The brain utilizes glucose as a primary energy substrate but also fatty acids for the β-oxidation in mitochondria. The β-oxidation is reported to occur mainly in astrocytes, but its capacity and efficacy against different fatty acids remain unknown. Here, we show the fatty acid preference for the β-oxidation in mitochondria of murine cultured astrocytes. Fatty acid oxidation assay using an extracellular flux analyzer showed that saturated or monosaturated fatty acids, palmitic acid and oleic acid, are preferred substrates over polyunsaturated fatty acids like arachidonic acid and docosahexaenoic acid. We also report that fatty acid binding proteins expressed in the astrocytes contribute less to fatty acid transport to mitochondria for β-oxidation. Our results could give insight into understanding energy metabolism through fatty acid consumption in the brain.

Laarni Grace Corales

Hitoshi Inada

Yuji Owada

Noriko Osumi

Genes to Cells

GENES TO CELLS 为发表描述分子和细胞生物学重要方面的论文提供了一个国际论坛。该杂志旨在发表在相关领域提供概念性进展的论文。将特别强调旨在了解生物学事件的基本机制的工作。

Genes to Cells is an international forum dedicated to publishing important research papers in the field of molecular and cellular biology. The journal aims to present conceptual advancements in related areas, with a particular emphasis on studies that seek to understand the fundamental mechanisms underlying biological events.

《Genes to Cells》是一个国际论坛，专注于发表分子和细胞生物学领域的重要研究论文。该杂志旨在发布在相关领域内提供概念性进展的研究成果，特别强调揭示生物学事件基本机制的研究工作。

Category	Quartile
生物学	4
生物学, 细胞生物学	4
生物学, 遗传学	4

Fatty acid preference for beta‐oxidation in mitochondria of murine cultured astrocytes

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Journal Info

Category	Quartile
GENETICS & HEREDITY	4