Anterior cruciate ligament (ACL) rupture occurs in hundreds of thousands of active adolescents and young adults each year. Despite current treatment, posttraumatic osteoarthritis following these injuries is common in these young patients. Thus, there is widespread clinical and scientific interest in improving patient outcomes and preventing osteoarthritis. The current emphasis on the removal of the torn ACL and subsequent replacement with a tendon graft (ACL reconstruction) stems from adherence to a long-held and widely accepted doctrine that the ACL has only a limited healing response and, therefore, cannot heal or regenerate with suture repair. Recent work has shown that, despite an active biologic response in the ACL after injury, the two ends of the torn ligament never reconnect. Additional studies have detailed findings after placement of a substitute provisional scaffold in the wound site of the ACL injury to bridge the gap and initiate healing of the ruptured ligament after primary repair. This technique, called enhanced primary repair, has significant potential advantages over current ACL reconstruction techniques, including the preservation of the complex attachment sites and innervation of these structures, thus retaining much of the biomechanical and proprioceptive function of these tissues. This manuscript summarizes the recent in vitro and in vivo studies in the area of enhancing ACL healing using biologic supplementation. Subsequent work in this area may lead to the development of a novel approach to treat this important injury. Anterior cruciate ligament (ACL) rupture occurs in hundreds of thousands of active adolescents and young adults each year. Despite current treatment, posttraumatic osteoarthritis following these injuries is common in these young patients. Thus, there is widespread clinical and scientific interest in improving patient outcomes and preventing osteoarthritis. The current emphasis on the removal of the torn ACL and subsequent replacement with a tendon graft (ACL reconstruction) stems from adherence to a long-held and widely accepted doctrine that the ACL has only a limited healing response and, therefore, cannot heal or regenerate with suture repair. Recent work has shown that, despite an active biologic response in the ACL after injury, the two ends of the torn ligament never reconnect. Additional studies have detailed findings after placement of a substitute provisional scaffold in the wound site of the ACL injury to bridge the gap and initiate healing of the ruptured ligament after primary repair. This technique, called enhanced primary repair, has significant potential advantages over current ACL reconstruction techniques, including the preservation of the complex attachment sites and innervation of these structures, thus retaining much of the biomechanical and proprioceptive function of these tissues. This manuscript summarizes the recent in vitro and in vivo studies in the area of enhancing ACL healing using biologic supplementation. Subsequent work in this area may lead to the development of a novel approach to treat this important injury.

Martha M. Murray

Clinics in Sports Medicine

运动医学诊所是骨科医生以及物理医学和康复领域的理想选择，提供最新的患者管理趋势和该领域最新进展的最新信息。每年出版四期——1 月、4 月、7 月和 10 月——每期关注运动医学的一个主题，从脊柱、膝盖、头部和颈部受伤，到创伤、成像和康复。运动医学诊所自 1999 年以来一直由受人尊敬的整形外科医生 MARK D. MILLER 编辑。

Clinics in Sports Medicine is an ideal choice for orthopedic surgeons and professionals in physical medicine and rehabilitation, providing the latest information on patient management trends and advancements in the field. The journal publishes four issues annually—in January, April, July, and October—each focusing on a specific theme in sports medicine, ranging from injuries of the spine, knee, head, and neck to trauma, imaging, and rehabilitation. Since 1999, Clinics in Sports Medicine has been edited by the esteemed orthopedic surgeon MARK D. MILLER.

《Clinics in Sports Medicine》是骨科医生以及物理医学和康复领域的理想选择，提供最新的患者管理趋势和该领域最新进展的信息。该期刊每年出版四期——分别在1月、4月、7月和10月，每期专注于运动医学的一个主题，涵盖从脊柱、膝盖、头部和颈部受伤到创伤、成像和康复等内容。自1999年以来，《Clinics in Sports Medicine》由受人尊敬的整形外科医生MARK D. MILLER编辑。

Current Status and Potential of Primary ACL Repair

This manuscript summarizes the recent in vitro and in vivo studies in the area of enhancing ACL healing using biologic supplementation and may lead to the development of a novel approach to treat this important injury.

Category	Quartile
医学	3
医学, 运动科学	3

Current Status and Potential of Primary ACL Repair

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Category	Quartile
SPORT SCIENCES	2