Two-component systems (TCSs) are diverse cell signaling pathways that play a significant role in coping with a wide range of environmental cues in both prokaryotic and eukaryotic organisms. These transduction circuitries are primarily governed by histidine kinases (HKs), which act as sensing proteins of a broad variety of stressors. To date, nineteen HK groups have been previously described in the fungal kingdom. However, the structure and distribution of these prominent sensing proteins were hitherto investigated in a limited number of fungal species. In this study, we took advantage of recent genomic resources in fungi to refine the fungal HK classification by deciphering the structural diversity and phylogenetic distribution of HKs across a large number of fungal clades. To this end, we browsed the genome of 91 species representative of different fungal clades, which yielded 726 predicted HK sequences. A domain organization analysis, coupled with a robust phylogenomic approach, led to an improved categorization of fungal HKs. While most of the compiled sequences were categorized into previously described fungal HK groups, some new groups were also defined. Overall, this study provides an improved overview of the structure, distribution, and evolution of HKs in the fungal kingdom.

Sara Mina

Anaïs Hérivaux

Hajar Yaakoub

Vincent Courdavault

Méline Wéry

Nicolas Papon

Current Genetics

CURRENT GENETICS 发表真核和原核微生物和细胞器的遗传、基因组、分子和系统级分析。所有文章均经过同行评审。该杂志欢迎采用任何类型的研究方法提交，无论是分析（旨在更好地理解）、应用（旨在实际应用）、合成或理论。CURRENT GENETICS 不再接受描述线粒体/叶绿体基因组序列的手稿少数种类。仍将考虑涵盖包含大量物种的序列比较和分析的手稿。

CURRENT GENETICS publishes genetic, genomic, molecular, and systems-level analyses of eukaryotic and prokaryotic microorganisms and organelles. All articles undergo peer review. The journal welcomes submissions employing any type of research methodology, whether analytical (aimed at better understanding), applied (aimed at practical application), synthetic, or theoretical. CURRENT GENETICS no longer accepts manuscripts that solely describe mitochondrial or chloroplast genome sequences, but will still consider manuscripts covering sequence comparisons and analyses involving a large number of species.

CURRENT GENETICS 发表关于真核生物和原核生物及其细胞器的遗传、基因组、分子和系统级分析。所有文章均经过同行评审。该杂志欢迎采用各种研究方法的投稿，无论是分析性研究（旨在深入理解）、应用性研究（旨在实际应用）、综合性研究还是理论研究。CURRENT GENETICS 不再接受仅描述线粒体或叶绿体基因组序列的手稿，但仍会考虑涉及大量物种的序列比较和分析的手稿。

Category	Quartile
生物学	4
生物学, 遗传学	4

Structure and distribution of sensor histidine kinases in the fungal kingdom

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