The distribution of T lymphocyte subsets was determined in 22 patients with endometrial carcinoma stage I. Following surgery and postoperative radiotherapy the patients had been randomized® into two groups: group A patients received no further treatment, whereas group B patients were treated with 17 a-hydroxyprogesterone caproate for one year. T cells and T cell subsets were estimated by an indirect immunofluorescence technique using the monoclonal antibodies UCHT3 (mature T cells), OKT4 (T helper cells), and OKT8 (T suppressor/cytotoxic cells). When examined 3–12 months after randomization the two groups had similar numbers of UCHT3+ cells and OKT4+ cells. Group B patients, however, had a significantly lower proportion of OKT8+ cells and hence a significantly higher OKT4/OKT8 ratio than group A patients. It is concluded that progestogen therapy has some immunomodulating effects.

MATHIAS ONSRUD

INFLUENCE OF PROGESTOGEN THERAPY ON T LYMPHOCYTE SUBSETS

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