Abstract Recent advancements in nanotechnology have spotlighted lipid nanocarriers as potent mediums for drug delivery, with solid lipid nanocarriers (SLNs) emerging as a key focus due to their unique structural attributes. This research specifically addresses the development and evaluation of the anti-inflammatory properties of SLNs loaded with sodium aescinate. To identify the most effective composition, a detailed pseudo-ternary phase diagram was employed. The production process of these SLNs involved sophisticated high-pressure homogenization techniques. For characterization, the average particle size and zeta potential were precisely measured using advanced laser diffractometry. Additionally, to ascertain the effectiveness of the drug encapsulation, the SLNs underwent a rigorous high-speed centrifugation process, enabling accurate determination of both the encapsulation efficiency and drug-loading capacity. The results of this research reveal that a relatively refined method for determining sodium aescinate content has been established, and a reasonable formulation has been selected for the preparation of sodium aescinate solid lipid nanoparticles. The average particle size was 142.32 ± 0.17 nm, the zeta potential was 1.60 ± 0.32 mV, and the encapsulation rate was 73.93 ± 4.65%. The drug loading was 13.41 ± 1.25%. In conclusion, this method can produce stable solid lipid nanoparticles containing sodium aescinate with uniform particle size, even distribution after encapsulation, and significant anti-inflammatory activity.

Xiaohong Jiang

Zhongfei Shen

Bin Shen

Ying Sun

Open Chemistry

OPEN CHEMISTRY 是一本经过同行评审的开放获取期刊，持续发表化学领域的原创研究、评论和简短交流。中心目标是为所有学科的研究人员提供一个展示他们发现的中心，并成为讨论该领域重要问题的论坛。该杂志是基础化学前沿研究的主要来源，它为世界各地的作者提供高质量的同行评审服务。此外，它允许世界各地的图书馆避免订阅多个本地出版物，而是从一个可供整个科学界使用的单一来源接收所有必要的化学研究。

Open Chemistry is a peer-reviewed open access journal that continuously publishes original research, reviews, and brief communications in the field of chemistry. Its central aim is to provide a platform for researchers from all disciplines to showcase their findings and to serve as a forum for discussing significant issues in the field. This journal is a major source of cutting-edge research in fundamental chemistry, offering high-quality peer review services to authors worldwide. Furthermore, it allows libraries around the globe to avoid subscribing to multiple local publications, instead receiving all necessary chemical research from a single source accessible to the entire scientific community.

《Open Chemistry》是一本经过同行评审的开放获取期刊，持续发表化学领域的原创研究、评论和简短交流。其核心目标是为各学科的研究人员提供一个展示研究成果的平台，并成为讨论该领域重要问题的论坛。这本期刊是基础化学前沿研究的重要来源，为全球作者提供高质量的同行评审服务。此外，它使得世界各地的图书馆能够避免订阅多个本地出版物，而是从一个可供整个科学界使用的单一来源获取所有必要的化学研究。

Category	Quartile
化学	4
化学, 化学综合	4

Preparation and pharmacodynamic evaluation of sodium aescinate solid lipid nanoparticles

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Journal Info

Category	Quartile
CHEMISTRY, MULTIDISCIPLINARY	3