Multiple viral pathogens can pose a significant health risk to individuals. As a recent example, the &amp;#946;-coronavirus family virion, SARS-CoV-2, has quickly evolved as a pandemic leading to coronavirus disease 2019 (COVID-19) and has been declared by the World Health Organization as a Public Health Emergency of International Concern. To date, no definitive treatment or vaccine application exists for COVID-19. Although new investigations seek to repurpose existing antiviral treatments for COVID-19, innovative treatment strategies not normally considered to have antiviral capabilities may be critical to address this global concern. One such avenue that may prove to be exceedingly fruitful and offer exciting potential as new antiviral therapy involves the mechanistic target of rapamycin (mTOR) and its associated pathways of mTOR Complex 1 (mTORC1), mTOR Complex 2 (mTORC2), and AMP activated protein kinase (AMPK). Recent work has shown that mTOR pathways in conjunction with AMPK may offer valuable targets to control cell injury, oxidative stress, mitochondrial dysfunction, and the onset of hyperinflammation, a significant disability associated with COVID-19. Furthermore, pathways that can activate mTOR may be necessary for anti-hepatitis C activity, reduction of influenza A virus replication, and vital for type-1 interferon responses with influenza vaccination. Yet, important considerations for the development of safe and effective antiviral therapy with mTOR pathways exist. Under some conditions, mTOR can act as a double edge sword and participate in virion replication and virion release from cells. Future work with mTOR as a potential antiviral target is highly warranted and with a greater understanding of this novel pathway, new treatments against several viral pathogens may successfully emerge.

Kenneth Maiese

Current Neurovascular Research

当前的神经血管研究为发表科学严谨的研究提供了一个跨平台，这些研究解决了神经科学中神经元和血管起源的疾病机制。该杂志作为一个国际论坛，出版新颖和原创作品以及及时的神经科学研究文章、细胞发育障碍、可塑性和退化学科的全长/迷你评论，弥合了基础科学研究和临床发现之间的差距。当前的神经血管研究强调阐明疾病机制，包括细胞和分子，这可能会影响神经元和血管疾病的独特治疗策略的发展。

Current Neurovascular Research is an interdisciplinary platform dedicated to publishing scientifically rigorous research that explores the mechanisms of neuron and vascular-related diseases in neuroscience. As an international forum, the journal publishes novel and original research findings, as well as timely articles, full-length and mini-reviews in the fields of neuroscience, cellular developmental disorders, plasticity, and degeneration, aiming to bridge the gap between basic scientific research and clinical discoveries. Current Neurovascular Research emphasizes elucidating disease mechanisms, including cellular and molecular studies, which may advance the development of unique therapeutic strategies for neuron and vascular diseases.

《Current Neurovascular Research》是一个跨学科的平台，致力于发表科学严谨的研究，探讨神经科学中神经元和血管相关疾病的机制。作为一个国际论坛，该杂志发布新颖且原创的研究成果，以及及时的神经科学研究文章、细胞发育障碍、可塑性和退化领域的全长和迷你评论，旨在弥合基础科学研究与临床发现之间的差距。《Current Neurovascular Research》强调阐明疾病机制，包括细胞和分子层面的研究，这些研究可能会推动针对神经元和血管疾病的独特治疗策略的发展。

The Mechanistic Target of Rapamycin (mTOR): Novel Considerations as an Antiviral Treatment

Future work with mTOR as a potential antiviral target is highly warranted and with a greater understanding of this novel pathway, new treatments against several viral pathogens may successfully emerge.

Category	Quartile
医学	4
医学, 临床神经病学	4
医学, 神经科学	4

The Mechanistic Target of Rapamycin (mTOR): Novel Considerations as an Antiviral Treatment

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