Pentafluorosulfanylation of Acrylamides: The Synthesis of SF5-Containing Isoquinolinediones with SF5Cl
丙烯酰胺的五氟硫烷基化:含SF5的异喹啉二酮与SF5Cl的合成
Xinqiang Tan, Yuezhen Li, Ziyou Hao, Jia Wang, Xiangqian Liu, Bingqing Liu, Jianmei Yuan, Lizhen Fang, Ping-Xin Zhou, Yingling Wang
期刊: The Journal of Organic Chemistry
摘要
We disclose herein an efficient and facile method for the synthesis of SF5-containing isoquinolinediones with an all-carbon quaternary stereocenter via intramolecular pentafluorosulfanylation of acrylamides using SF5Cl as a pentafluorosulfanylation reagent. The protocol proceeds under mild reaction conditions and enjoys a broad substrate scope, wide functional group compatibility, and high atom- and step-economy. A radical mechanism involving the SF5 radical cascade addition/cyclization of acrylamides is proposed.
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ISSN: 0022-3263
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