Serial determinations of total serum glycoprotein, seromucoid hexose, total serum protein and antibody levels were carried out in four groups of adult, male albino rabbits subjected to the following experimental procedures: (a) 400 r whole body X-irradiation, (b) immunization with 10 mg I 131 BSA, (c) irradiation followed by antigen injection 24 hours later, and (d) bleeding controls. The dose of radiation employed suppressed the antibody response of (c). Significant increases in total glycoprotein and seromucoid hexose occurred 24 hours after exposure in the irradiated groups and persisted for 4 days. Pronounced decreases in total protein were observed in (a), (b), and (c). It was concluded that increases in serum glycoproteins were related primarily to tissue injury.

Henry E. Weimer

Marvin B. Rittenberg

THE SERUM GLYCOPROTEIN RESPONSE FOLLOWING X-IRRADIATION AND PRIMARY IMMUNIZATION IN THE RABBIT

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