Domoic acid: Attributes, exposure risks, innovative detection techniques and therapeutics

岩藻毒素:特性、暴露风险、创新检测技术及疗法

Abdullah F. Saeed, Saima Ashraf Awan, Sumei Ling, Rongzhi Wang, Shihua Wang

DOI: 10.1016/j.algal.2017.02.007

期刊: Algal Research

摘要

Domoic acid is a potent neurotoxin, glutamate agonist and natural marine biotoxin. It is produced by several diatom algal species of genetically diverse genus Pseudo-nitzschia, red alga Chondria armata and other related species. Historically, widespread domoic acid intoxication incidents have occurred globally. Particularly, in 1987, domoic acid caused an outbreak of human poisoning in Canada by the consumption of contaminated blue mussels (Mytilus edulis) that gave rise to countless clinical illnesses and human deaths. The toxin targets glutamate receptors present in various vital organs and a cascade of ailments characterized the poisoning. The specifically listed neural disorders include memory impairment, coma, recurrent seizures, and epilepsy that led to the name amnesic shellfish poisoning. The occurrence of domoic acid in test samples has been determined by various novel techniques such as liquid chromatography-mass spectrometry, biosensors, enzyme-linked immunosorbent assay and other related hi-tech detection methods. Since the Canada incident, the toxin has intoxicated several marine mammals, sea birds, and contaminated colonized coastal waters around the globe. Subsequently, domoic acid producing algal blooms are accelerating frequently worldwide. Therefore, it poses a global health, safety threat and exposure risks to a significant number of marine and human lives. Genetics of domoic acid producing algal species, molecular markers and therapeutics are currently least known. Therefore, the present review addresses intriguing attributes of domoic acid, such as physicochemical, pharmacological and biological features, sources, and genetic diversity of the producers. In addition, exposure risks including toxicologic pathology of domoic acid poisoning, neurotoxic pathways, detection methods and therapeutics have been inclusively discussed.

文章解读

研飞AI智能解析 PDF,回答研究者问题,助你秒懂论文

免费下载

期刊信息

期刊:

ISSN: 2211-9264

国际分区

类目分区
BIOTECHNOLOGY & APPLIED MICROBIOLOGY1

国内分区

类目分区
生物学2
生物学, 生物工程与应用微生物2
Built withby Ivy Science
Copyright © 2020-2024
版权所有:南京青藤格致信息科技有限公司
隐私和监管政策
苏ICP备20040574号-1
ICP许可证: 苏B2-20220377