The objective of this study was to examine the cytotoxic effects of farrerol on esophageal cancer cells. Firstly, the influence of farrerol on the vitality of esophageal cancer cells (EC109) was examined, revealing a significant detrimental effect on cellular viability. Subsequently, a flow cytometry examination was conducted to examine its role in the apoptotic process and cell cycle of EC109 cells. Farrerol has been found to effectively induce apoptosis and arrest the cell cycle at the G2/M phase. In addition, it leads to the activation of caspase-9, an increase in NADPH oxidase activity, and the formation of reactive oxygen species, while simultaneously reducing the level of glutathione in EC109 cells. Furthermore, a model of athymic nude mice was created by injecting EC109 cells to examine the pharmacological efficacy of farrerol. The results indicated that farrerol significantly decreases the size of the tumor and enhances the body weight of the mice. The western blot examination demonstrated that it suppressed the activity of phosphorylated epidermal growth factor receptor (p-EGFR) and phospho-transducer and activator of transcriptor-3 (p-STAT3) in the mice. The results of our study effectively showcased the pharmacological advantages of farrerol in treating esophageal cancer, owing to its multifactorial impact.

Yangyang Bai

Tao Zhang

Shaik Althaf Hussain

Turki Mayudh Alrubie

Feiyan Long

Revista Brasileira de Farmacognosia

The Brazilian Journal of Pharmacognosy is a scientific journal edited and published by the Brazilian Society of Pharmacognosy, an association that brings together researchers, students and professionals who study and investigate the physical, chemical and biological drugs, especially those of vegetable origin, substances isolated and such as the potential source of drugs of natural origin. It is available in printed form for its members and subscribers and openly on the Internet in all your numbers and content. The articles published are original research contributions. To evaluate the work use is made of international standards and is held by the ad hoc advisers, which reflects the quality and credibility of the journal. The BJP is published since 1986.

The Brazilian Journal of Pharmacognosy is a scientific journal edited and published by the Brazilian Society of Pharmacognosy. This association brings together researchers, students, and professionals who study and investigate the physical, chemical, and biological properties of drugs, especially those of plant origin, isolated substances, and their potential as sources of natural drugs. The journal is available in printed form for its members and subscribers, and all issues and content are openly accessible on the Internet. The published articles are original research contributions. The evaluation process adheres to international standards and is conducted by ad hoc reviewers, reflecting the quality and credibility of the journal. The Brazilian Journal of Pharmacognosy has been published since 1986.

《Revista Brasileira de Farmacognosia》是由巴西药用植物学会编辑和出版的科学期刊。该学会汇聚了研究、学习和探讨植物药物及其物理、化学和生物特性的研究人员、学生和专业人士。期刊专注于植物来源的药物、分离的物质以及天然药物的潜在来源。期刊以印刷形式提供给会员和订阅者，同时在互联网上公开发布所有期号和内容。所发表的文章均为原创研究贡献，评审工作遵循国际标准，由特邀顾问进行评审，确保期刊的质量和可信度。《Revista Brasileira de Farmacognosia》自1986年起出版。

Category	Quartile
医学	4
医学, 药物化学	4
医学, 药学	4

Anti-cancer Potential of Farrerol Against Esophageal Carcinoma via Inhibiting STAT3-EGFR Signaling Pathway

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Journal Info

Category	Quartile
PHARMACOLOGY & PHARMACY	4