Rational design of naphthoquinone-based antibacterial agents through iridium-catalyzed enantioselective β-allenylation of 2-hydroxynaphthoquinones
基于铱催化的2-羟基萘醌的手性β-烯丙基化反应的萘醌类抗菌剂的合理设计
Aditya Chakrabarty, Komal Jaiswal, Mrinmoy De, Santanu Mukherjee
DOI: 10.1039/d4qo01134a
期刊: Organic Chemistry Frontiers
摘要
The first Ir-catalyzed enantioselective β-allenylation of 2-hydroxynaphthoquinones is developed. The β-allenylic lawsone derivatives displayed remarkable potency against Gram-positive MRSA strain and low toxicity against mammalian cell lines.
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ISSN: 2052-4110
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