Women have more body fat than men, but in contrast to the deleterious metabolic consequences of the central obesity typical of men, the pear-shaped body fat distribution of many women is associated with lower cardiometabolic risk. To understand the mechanisms regulating adiposity and adipose tissue distribution in men and women, significant research attention has focused on comparing adipocyte morphological and metabolic properties, as well as the capacity of preadipocytes derived from different depots for proliferation and differentiation. Available evidence points to possible intrinsic, cell autonomous differences in preadipocytes and adipocytes, as well as modulatory roles for sex steroids, the microenvironment within each adipose tissue, and developmental factors. Gluteal-femoral adipose tissues of women may simply provide a safe lipid reservoir for excess energy, or they may directly regulate systemic metabolism via release of metabolic products or adipokines. We provide a brief overview of the relationship of fat distribution to metabolic health in men and women, and then focus on mechanisms underlying sex differences in adipose tissue biology.

Kalypso Karastergiou

Steven R Smith

Andrew S Greenberg

Susan K Fried

Biology of Sex Differences

与任何其他科学期刊不同，《性别差异生物学》侧重于生理、行为和疾病方面的性别差异，从分子到表型，并结合了基础和临床研究。该杂志旨在提高对基本原则的理解，并促进针对性别差异的治疗和诊断工具的开发。这本开放获取期刊是性别差异研究组织备受推崇的官方期刊，由女性健康研究协会共同出版。主题领域包括但不限于以下方面的性别差异：基因组学；微生物组；表观遗传学；分子和细胞生物学；组织生物学；生理;任何系统中的组织系统的相互作用，包括脂肪、行为、心血管、免疫、肌肉、神经、肾脏和骨骼；关于疾病性别差异或对治疗反应的临床研究

The journal "Biology of Sex Differences" is a unique scientific publication that focuses on sex differences in physiology, behavior, and disease, spanning from molecular to phenotypic levels, and integrating both basic and clinical research. The journal aims to enhance the understanding of fundamental principles related to sex differences and to promote the development of targeted diagnostic and therapeutic tools. As an open-access journal, it is the official publication of the Organization for the Study of Sex Differences, co-published by the Society for Women's Health Research. The thematic areas covered include, but are not limited to, sex differences in genomics, microbiomics, epigenetics, molecular and cellular biology, tissue biology, physiology, and the interactions of organizational systems in various systems, including adipose, behavioral, cardiovascular, immune, muscular, neurological, renal, and skeletal systems; as well as clinical research on disease sex differences or responses to treatment.

《Biology of Sex Differences》是一份独特的科学期刊，专注于生理、行为和疾病方面的性别差异，涵盖从分子到表型的各个层面，并结合基础与临床研究。该期刊旨在加深对性别差异基本原则的理解，并促进针对这些差异的治疗和诊断工具的开发。作为一份开放获取的期刊，它是性别差异研究组织的官方期刊，由女性健康研究协会共同出版。期刊的主题领域包括但不限于以下方面的性别差异：基因组学、微生物组、表观遗传学、分子与细胞生物学、组织生物学、生理学，以及在不同系统中组织系统的相互作用，包括脂肪、行为、心血管、免疫、肌肉、神经、肾脏和骨骼等；同时也涵盖关于疾病性别差异或对治疗反应的临床研究。

Sex differences in human adipose tissues – the biology of pear shape

An overview of the relationship of fat distribution to metabolic health in men and women is provided, and mechanisms underlying sex differences in adipose tissue biology are focused on.

Category	Quartile
医学	2
医学, 内分泌学与代谢	2
医学, 遗传学	2

Sex differences in human adipose tissues – the biology of pear shape

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Journal Info

Category	Quartile
GENETICS & HEREDITY	1