Palladium-Catalyzed Chemo- and Regioselective C–H Bond Functionalization of Phenols with 1,3-Dienes
钯催化苯酚与1,3-二烯的化学和区域选择性C-H键功能化
Ke-Qin Wu, Hui Li, Ao Zhou, Wei-Ran Yang, Qin Yin
期刊: The Journal of Organic Chemistry
摘要
Chemo- and site-selective functionalization of phenols offers a rapid strategy for the synthesis of phenol derivatives with diverse structures. Herein, we report a Pd-catalyzed regioselective C-H bond allylic alkylation of phenols with 1,3-dienes, which has precision reactivity at the ortho C-H bond of 2-naphthols, 1-naphthols, and electron-rich phenols. The reaction is accelerated by a diphosphine ligand, does not need any other additive, and features broad substrate scope and good chemo- and regioselectivity. In addition, we have also investigated the asymmetric variant, and the product could be achieved in up to 55% ee.
文章解读
研飞AI智能解析 PDF,回答研究者问题,助你秒懂论文
免费下载期刊信息
期刊:
ISSN: 0022-3263
国际分区
类目 | 分区 |
CHEMISTRY, ORGANIC | 1 |
国内分区
类目 | 分区 |
化学 | 2 |
化学, 有机化学 | 2 |