Summary Treatment of uremia by hemodialysis has become widespread over the last 40 years and has improved substantially over that time. However, people treated with this modality continue to suffer from multiple disabilities. Retention of organic solutes, especially those poorly removed by hemodialysis, likely contributes to these disabilities. Certain classes of solutes are removed less well than urea by hemodialysis and by the normal kidney. These include protein-bound solutes, relatively large solutes, sequestered compounds, and substances removed at rates higher than urea by the normal kidney. Several strategies could be used to discover the solutes responsible for residual morbidities in standardly dialyzed people. Rather than continue to focus only on urea removal as an index for dialysis adequacy, finding additional approaches for removing toxic solutes with characteristics different from urea (and the similar small solutes it represents) is a desirable and feasible goal.

Mirela Dobre

Timothy W. Meyer

Thomas H. Hostetter

Clinical Journal of the American Society of Nephrology

CJASN 文章的目标是快速有效地传达肾脏病学临床和转化研究中最重要的进展，包括研究方法和护理提供的创新；将这些进展置于未来研究方向和患者护理的背景中；并成为可能影响肾脏病临床实践的一个重要问题，尤其是在美国。

The Clinical Journal of the American Society of Nephrology aims to rapidly and effectively communicate the most significant advancements in clinical and translational research in nephrology. The articles cover innovative research methods and care delivery, placing these advancements in the context of future research directions and patient care, striving to be a key reference that may influence clinical practice in nephrology, particularly in the United States.

《Clinical Journal of the American Society of Nephrology》旨在快速有效地传达肾脏病学领域内临床和转化研究的最新进展。这些文章不仅涵盖了研究方法和护理创新，还将这些进展置于未来研究方向和患者护理的背景中，力求成为影响肾脏病临床实践的重要参考，尤其是在美国。

Searching for Uremic Toxins

Rather than continue to focus only on urea removal as an index for dialysis adequacy, finding additional approaches for removing toxic solutes with characteristics different from urea is a desirable and feasible goal.

Category	Quartile
医学	1
医学, 泌尿学与肾脏学	1

Searching for Uremic Toxins

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Journal Info

Category	Quartile
UROLOGY & NEPHROLOGY	1