The broad availability of smartphones has provided new opportunities to develop less expensive, portable, and integrated point-of-care (POC) platforms. Here, a platform that consists of three main components is introduced: a portable housing, a centrifugal microfluidic disc, and a mobile phone. The mobile phone supplies the electrical power and serves as an analysing system. The low-cost housing made from cardboard serves as a platform to conduct tests. The electrical energy stored in mobile phones was demonstrated to be adequate for spinning a centrifugal disc up to 3000 revolutions per minute (RPM), a rotation speed suitable for majority of centrifugal microfluidics-based assays. For controlling the rotational speed, a combination of magnetic and acoustic tachometry using embedded sensors of the mobile phone was used. Experimentally, the smartphone-based tachometry was proven to be comparable with a standard laser-based tachometer. As a proof of concept, two applications were demonstrated using the portable platform: a colorimetric sandwich immunoassay to detect interleukin-2 (IL-2) having a limit of detection (LOD) of 65.17 ng/mL and a fully automated measurement of hematocrit level integrating blood-plasma separation, imaging, and image analysis that takes less than 5 mins to complete. The low-cost platform weighing less than 150 g and operated by a mobile phone has the potential to meet the REASSURED criteria for advanced diagnostics in resource limited settings.

Noa Lapins

Ahmad S. Akhtar

Indradumna Banerjee

Amin Kazemzadeh

Inês F. Pinto

Aman Russom

Biomedical Microdevices

BIOMEDICAL MICRODEVICES: BIOMEMS AND BIOMEDICAL NANOTECHNOLOGY 是一本跨学科期刊，致力于研究微机电系统 (BIOMEMS) 和纳米技术在医学和生物学中的医学诊断和治疗应用的各个方面。感兴趣的一般主题包括设计、表征、微制造系统的测试、建模和临床验证，以及它们在芯片上和更大功能单元中的集成。该杂志的具体兴趣包括神经刺激和记录系统、生物分离技术（如纳米过滤器和电泳设备）、小型化分析和 DNA 识别系统、生物传感器以及用于细胞和组织研究、组织工程、细胞移植和药物和生物分子的受控释放。鼓励对生物医学微型器件和纳米技术的材料科学、生物化学和物理学的基础和应用研究进行报告。感兴趣的领域的非详尽列表包括：纳米粒子合成、表征和动物模型中治疗或成像功效的验证；生物相容性；微制造装置的生化修饰，参考非特异性蛋白质吸附，以及微/纳米制造表面上蛋白质的主动固定和图案化；微纳通道中的流体动力学；微/纳米加工系统的机电和结构响应；微型设备与细胞和组织的相互作用，包括生物相容性和生物降解研究；系统特性的变化作为微/纳米加工参数的函数。

Biomedical Microdevices is an interdisciplinary journal dedicated to the study of microelectromechanical systems (BIOMEMS) and the applications of nanotechnology in medical diagnostics and therapeutics in the fields of medicine and biology. The journal covers a wide range of topics including design, characterization, testing of microfabrication systems, modeling, and clinical validation, as well as the integration of these technologies in chips and larger functional units. Specific areas of interest include neural stimulation and recording systems, bioseparation technologies (such as nanofilters and electrophoresis devices), miniaturized analytical and DNA recognition systems, biosensors, and controlled release of drugs and biomolecules for cell and tissue studies, tissue engineering, and cell transplantation. The journal encourages reports on fundamental and applied research in materials science, biochemistry, and physics related to biomedical microdevices and nanotechnology. Areas of interest include but are not limited to: synthesis and characterization of nanoparticles and validation of therapeutic or imaging efficacy in animal models; biocompatibility; biochemical modification of microfabricated devices, particularly regarding nonspecific protein adsorption, and active immobilization and patterning of proteins on micro/nanofabricated surfaces; fluid dynamics in micro/nanofluidic channels; electromechanical and structural responses of micro/nanofabrication systems; interactions of microdevices with cells and tissues, including studies on biocompatibility and biodegradability; and variations in system characteristics as a function of micro/nanofabrication parameters.

《Biomedical Microdevices》是一本跨学科的期刊，专注于微机电系统（BIOMEMS）和纳米技术在医学和生物学领域的诊断和治疗应用。期刊涵盖的主题包括设计、表征、微制造系统的测试、建模和临床验证，以及这些技术在芯片和更大功能单元中的集成。具体研究兴趣包括神经刺激和记录系统、生物分离技术（如纳米过滤器和电泳设备）、小型化分析和DNA识别系统、生物传感器，以及用于细胞和组织研究、组织工程、细胞移植和药物与生物分子的受控释放。期刊鼓励对生物医学微型器件和纳米技术的材料科学、生物化学和物理学的基础与应用研究进行报告。感兴趣的领域包括但不限于：纳米粒子的合成、表征及其在动物模型中的治疗或成像效果验证；生物相容性；微制造装置的生化修饰，特别是针对非特异性蛋白质吸附的研究，以及在微/纳米制造表面上蛋白质的主动固定和图案化；微纳通道中的流体动力学；微/纳米加工系统的机电和结构响应；微型设备与细胞和组织的相互作用，包括生物相容性和生物降解研究；以及系统特性如何随微/纳米加工参数的变化而变化。

Category	Quartile
医学	4
医学, 工程生物医学	4
医学, 纳米科技	4

Smartphone-driven centrifugal microfluidics for diagnostics in resource limited settings

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