Introduction: Pulmonary transit time (PTT) is the time it takes blood to pass from the right ventricle to the left ventricle via the pulmonary circulation, making it a potentially useful marker for heart failure. We assessed the association of PTT with diastolic dysfunction (DD) and mitral valve regurgitation (MVR). Methods: We evaluated routine stress perfusion cardiovascular magnetic resonance (CMR) scans in 83 patients including assessment of PTT with simultaneously available echocardiographic assessment. Relevant DD and MVR were defined as exceeding Grade I (impaired relaxation and mild regurgitation). PTT was determined from CMR rest perfusion scans. Normalized PTT (nPTT), adjusted for heart rate, was calculated using Bazett’s formula. Results: Higher PTT and nPTT values were associated with higher grade DD and MVR. The diagnostic accuracy for the prediction of DD as quantified by the area under the ROC curve (AUC) was 0.73 (CI 0.61–0.85; p = 0.001) for PTT and 0.81 (CI 0.71–0.89; p &lt; 0.001) for nPTT. For MVR, the diagnostic performance amounted to an AUC of 0.80 (CI 0.68–0.92; p &lt; 0.001) for PTT and 0.78 (CI 0.65–0.90; p &lt; 0.001) for nPTT. PTT values &lt; 8 s rule out the presence of DD and MVR with a probability of 70% (negative predictive value 78%). Conclusion: CMR‐derived PTT is a readily obtainable hemodynamic parameter. It is elevated in patients with DD and moderate to severe MVR. Low PTT values make the presence of DD and MVR—as assessed by echocardiography—unlikely.

Martin Segeroth

David Jean Winkel

Beat A. Kaufmann

Ivo Strebel

Shan Yang

Joshy Cyriac

Jakob Wasserthal

Michael Bach

Pedro Lopez-Ayala

Alexander Sauter

Christian Mueller

Jens Bremerich

Michael Zellweger

Philip Haaf

International Journal of Biomedical Imaging

The last quarter century has witnessed major advancements that have brought biomedical imaging to a paramount status in life sciences. As a prominent example, the National Institute of Biomedical Imaging and Bioengineering (NIBIB) was established in 2000 as the newest institute in the National Institutes of Health (NIH), USA. Generally speaking, the scope of biomedical imaging covers data acquisition, image reconstruction, and image analysis, involving theories, methods, systems, and applications. While tomographic and post-processing techniques become increasingly sophisticated, traditional and emerging modalities play more and more critical roles in anatomical, functional, cellular, and molecular imaging.

Over the last quarter-century, the field of biomedical imaging has undergone significant advancements, establishing its paramount importance in the life sciences. A notable example is the establishment of the National Institute of Biomedical Imaging and Bioengineering (NIBIB) in 2000, which became the newest institute within the National Institutes of Health (NIH) in the USA. Generally speaking, the scope of biomedical imaging includes data acquisition, image reconstruction, and image analysis, involving theories, methods, systems, and applications. As tomographic and post-processing techniques become increasingly sophisticated, both traditional and emerging modalities play increasingly critical roles in anatomical, functional, cellular, and molecular imaging.

在过去的四分之一个世纪中，生物医学成像领域经历了重大的进展，使其在生命科学中占据了重要地位。一个显著的例子是，生物医学成像与生物工程国家研究所（NIBIB）于2000年成立，成为美国国家卫生研究院（NIH）中最新的研究所。一般而言，生物医学成像的范围涵盖数据采集、图像重建和图像分析，涉及理论、方法、系统和应用。随着层析成像和后处理技术的日益复杂，传统和新兴成像方式在解剖、功能、细胞和分子成像中扮演着越来越重要的角色。

Noninvasive Assessment of Cardiopulmonary Hemodynamics Using Cardiovascular Magnetic Resonance Pulmonary Transit Time

无创评估心肺血流动力学使用心血管磁共振肺通过时间

Noninvasive Assessment of Cardiopulmonary Hemodynamics Using Cardiovascular Magnetic Resonance Pulmonary Transit Time

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Journal Info

Category	Quartile
ENGINEERING, BIOMEDICAL	2