Contents 1. Introduction 223 2. Klotho structure, function, and activity 224 3. Klotho and hippocampus 226 3.1 Klotho expression in the hippocampus 226 3.2 Klotho action on hippocampal-dependent cognition, behavior, and motor skills 227 3.3 Klotho action on hippocampal neurons 227 4. Conclusion and perspectives 238 Acknowledgments 239 References 239

Jennifer Mytych

Vitamins and Hormones

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

First published in 1943, the journal "Anxiety" is the longest-running serial published by Academic Press. In its early days, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. "Anxiety" continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

《Anxiety》期刊自1943年首次出版以来，一直是Academic Press出版的最长寿的系列期刊。在早期，维生素和激素的主题相对独立。如今，编辑委员会的成员在激素作用、维生素作用、X射线晶体结构、生理学和酶机制等领域具有丰富的专业知识。《Anxiety》期刊继续发表与内分泌学家、生物化学家、营养学家、药理学家、细胞生物学家和分子生物学家等相关的前沿综述。其他对生物活性分子（如激素和维生素）的结构和功能感兴趣的研究人员，仍然会向该系列寻求来自相关学科领先贡献者的全面综述。

类目	分区
医学	4
医学, 生化与分子生物学	4
医学, 内分泌学与代谢	4

Actions of Klotho on hippocampal neuronal cells

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期刊信息