Objective To investigate the efficacy and safety of creatine supplementation in fibromyalgia patients. Methods A 16‐week, randomized, double‐blind, placebo‐controlled, parallel‐group trial was conducted. Fibromyalgia patients were randomly assigned to receive either creatine monohydrate or placebo in a double‐blind manner. The patients were evaluated at baseline and after 16 weeks. Muscle function, aerobic conditioning, cognitive function, quality of sleep, quality of life, kidney function, and adverse events were assessed. Muscle phosphorylcreatine content was measured through 31 P magnetic resonance spectroscopy. Results After the intervention, the creatine group presented higher muscle phosphorylcreatine content when compared with the placebo group (+80.3% versus −2.7%; P = 0.04). Furthermore, the creatine group presented greater muscle strength than the placebo group in the leg press and chest press exercises (+9.8% and +1.2% for creatine versus −0.5% and −7.2% for placebo, respectively; P = 0.02 and P = 0.002, respectively). Isometric strength was greater in the creatine group than in the placebo group (+6.4% versus −3.2%; P = 0.007). However, no general changes were observed in aerobic conditioning, pain, cognitive function, quality of sleep, and quality of life. Food intake remained unaltered and no side effects were reported. Conclusion Creatine supplementation increased intramuscular phosphorylcreatine content and improved lower‐ and upper‐body muscle function, with minor changes in other fibromyalgia features. These findings introduce creatine supplementation as a useful dietary intervention to improve muscle function in fibromyalgia patients.

Christiano R. R. Alves

Bianca M. Santiago

Fernanda R. Lima

Maria C. G. Otaduy

Ana Luisa Calich

Aline C. C. Tritto

Ana Lúcia de Sá Pinto

Hamilton Roschel

Cláudia C. Leite

Fabiana B. Benatti

Eloisa Bonfá

Bruno Gualano

Arthritis Care & Research

ARTHRITIS CARE & RESEARCH 是美国风湿病学会和风湿病健康专业人员协会（学院的一个部门）的官方期刊，是一份同行评议的出版物，发表原创研究、评论文章和社论，以促进在风湿病临床实践。与风湿病患者的护理相关，主要主题是循证实践研究、临床问题、实践指南、教育、社会和公共卫生问题、卫生经济学、卫生保健政策以及风湿病实践的未来趋势。

Arthritis Care and Research is the official journal of the American College of Rheumatology and the Association of Rheumatology Health Professionals (a division of the college). This peer-reviewed publication features original research, review articles, and editorials aimed at advancing clinical practice in rheumatology. The journal primarily addresses topics related to the care of patients with rheumatic diseases, including evidence-based practice research, clinical issues, practice guidelines, education, social and public health issues, health economics, healthcare policy, and future trends in rheumatology practice.

《Arthritis Care and Research》是美国风湿病学会和风湿病健康专业人员协会（学院的一个部门）的官方期刊。这是一份经过同行评审的学术期刊，发表原创研究、评论文章和社论，旨在促进风湿病的临床实践。期刊主要关注与风湿病患者护理相关的主题，包括循证实践研究、临床问题、实践指南、教育、社会和公共卫生问题、卫生经济学、卫生保健政策以及风湿病实践的未来趋势。

Arthritis Care and Research

Creatine Supplementation in Fibromyalgia: A Randomized, Double‐Blind, Placebo‐Controlled Trial

The objective was to investigate the efficacy and safety of creatine supplementation in fibromyalgia patients and to establish a protocol for evaluating the safety and effectiveness of this treatment.

Category	Quartile
医学	2
医学, 风湿病学	3

Creatine Supplementation in Fibromyalgia: A Randomized, Double‐Blind, Placebo‐Controlled Trial

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