The association of elevated serum uric acid with the development of hypertension is established outside of pregnancy. We investigated whether first trimester uric acid was associated with the development of the following: gestational hypertension or pre-eclampsia, these outcomes stratified by presence of hyperuricemia at delivery since this denotes more severe disease,preterm birth, or small for gestational age (SGA). Uric acid was measured in 1,541 banked maternal plasma samples from a prior prospective cohort study that were collected at a mean gestational age of 9.0 (± 2.5) weeks. Polytomous regressions were performed and adjusted for parity and prepregnancy body mass index (BMI). First trimester uric acid in the highest quartile (>3.56 mg/dl) compared to lowest three quartiles was associated with an increased risk of developing pre-eclampsia (adjusted odds ratio (OR) = 1.82; 95% confidence interval (CI), 1.03–3.21) but not gestational hypertension. In women with hypertensive disease complicated by hyperuricemia at delivery, high first trimester uric acid was associated with a 3.22–fold increased risk of hyperuricemic gestational hypertension (HU) and a 3.65–fold increased risk of hyperuricemic pre-eclampsia (HPU). High first trimester uric acid was not associated with gestational hypertension or pre-eclampsia without hyperuricemia (H or HP) at delivery, preterm birth, or SGA. In women who developed hypertensive disease, elevated uric acid at delivery was only partly explained by elevated uric acid in the first trimester (r2 = 0.23). First trimester elevated uric acid was associated with later preeclampsia and more strongly with pre-eclampsia and gestational hypertension with hyperuricemia. American Journal of Hypertension advance online publication 20 January 2011; doi:10.1038/ajh.2010.262

S. K. Laughon

J. Catov

R. W. Powers

J. M. Roberts

R. E. Gandley

American Journal of Hypertension

《美国高血压杂志》是一份经过同行评审的月刊，为对高血压和相关心血管疾病领域的最高标准进行科学探究提供了一个论坛。该杂志发表关于基础科学、分子生物学、临床和实验性高血压、心脏病学、流行病学、小儿高血压、内分泌学、神经生理学和肾病学的高质量原创研究和评论文章。

The American Journal of Hypertension is a peer-reviewed monthly journal that provides a high-standard forum for scientific exploration in the field of hypertension and related cardiovascular diseases. The journal publishes high-quality original research and review articles on basic science, molecular biology, clinical and experimental hypertension, cardiology, epidemiology, pediatric hypertension, endocrinology, neurophysiology, and nephrology.

《美国高血压杂志》是一份经过同行评审的月刊，旨在为高血压及相关心血管疾病领域的科学研究提供一个高标准的论坛。该杂志发表关于基础科学、分子生物学、临床和实验性高血压、心脏病学、流行病学、小儿高血压、内分泌学、神经生理学和肾病学等领域的高质量原创研究和评论文章。

First Trimester Uric Acid and Adverse Pregnancy Outcomes

First trimester elevated uric acid was associated with later pre-eclampsia and more strongly with pre- eclampsian disease and gestational hypertension with hyperuricemia and gestations with hyperURicemia.

Category	Quartile
医学	3
医学, 外周血管病	3

First Trimester Uric Acid and Adverse Pregnancy Outcomes

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Journal Info

Category	Quartile
PERIPHERAL VASCULAR DISEASE	2