Novel secondary metabolites from marine macroorganisms and marine-derived microorganisms have been intensively investigated in the last few decades. Several classes of compounds, especially indole alkaloids, have been a target for evaluating biological and pharmacological activities. As one of the most promising classes of compounds, indole alkaloids possess not only intriguing structural features but also a wide range of biological/pharmacological activities including antimicrobial, anti-inflammatory, anticancer, antidiabetic, and antiparasitic activities. This review reports the indole alkaloids isolated during the period of 2016-2021 and their relevant biological/pharmacological activities. The marine-derived indole alkaloids reported from 2016 to 2021 were collected from various scientific databases. A total of 186 indole alkaloids from various marine organisms including fungi, bacteria, sponges, bryozoans, mangroves, and algae, are described. Despite the described bioactivities, further evaluation including their mechanisms of action and biological targets is needed to determine which of these indole alkaloids are worth studying to obtain lead compounds for the development of new drugs.

Joko Tri Wibowo

Peni Ahmadi

Siti Irma Rahmawati

Asep Bayu

Masteria Yunovilsa Putra

Anake Kijjoa

Marine Drugs

MARINE DRUGS (ISSN 1660-3397) 发表关于海洋药物研究、开发和生产的评论、定期研究论文和简短说明。我们的目标是鼓励科学家尽可能详细地发表他们的实验和理论研究，特别是生物活性化合物的合成程序和表征信息。实验部分的长度没有限制。

Marine Drugs (ISSN 1660-3397) publishes reviews, regular research articles, and short communications on the research, development, and production of marine drugs. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly regarding the synthesis procedures and characterization information of bioactive compounds. There is no limit on the length of the experimental section.

《Marine Drugs》 (ISSN 1660-3397) 发表关于海洋药物的研究、开发和生产的评论、定期研究论文和简短说明。我们的目标是鼓励科学家尽可能详细地发表他们的实验和理论研究，特别是生物活性化合物的合成程序和表征信息。实验部分的长度没有限制。

Marine-Derived Indole Alkaloids and Their Biological and Pharmacological Activities

Despite the described bioactivities, further evaluation including their mechanisms of action and biological targets is needed to determine which of these indole alkaloids are worth studying to obtain lead compounds for the development of new drugs.

Category	Quartile
医学	2
医学, 药物化学	2
医学, 药学	2

Marine-Derived Indole Alkaloids and Their Biological and Pharmacological Activities

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Journal Info

Category	Quartile
PHARMACOLOGY & PHARMACY	1