Respiratory infections in children, ranging from mild to severe, are a leading cause of school absences and medical visits, creating significant socio-economic burdens for families. Recent interest has focused on resveratrol, a natural polyphenol known for its antioxidant, anti-inflammatory, and antiviral properties. When combined with carboxymethyl-β-glucan (CM-glucan), a modified polysaccharide with immunostimulatory effects, this formulation has shown potential benefits in managing respiratory diseases. Our research examines five randomized clinical trials investigating the efficacy of resveratrol and CM-glucan nasal solutions in children. The trials included children with recurrent respiratory infections (RRIs) and allergic rhinitis. The results demonstrate significant reductions in key respiratory symptoms, including nasal congestion, sneezing, coughing, and fever. In addition to symptomatic relief, the treatment was associated with fewer medical visits, decreased medication use, and reduced school absences. Importantly, the combination also showed efficacy in decreasing wheezing episodes in non-atopic children with RRIs and improving symptoms of allergic rhinitis. While these findings are promising, the studies are limited by small sample sizes and short-term follow-up periods, raising questions about the long-term efficacy and safety of the treatment. Mild and transient nasal irritation was the only reported side effect. Based on these concepts, the combination of resveratrol and carboxymethyl-β-glucan could be considered a valuable add-on strategy, complementing standard pharmacological treatments for pediatric respiratory infections and allergic conditions.

Cristiana Indolfi

Giulio Dinardo

Angela Klain

Carolina Grella

Maria Maddalena Marrapodi

Fabio Decimo

Giorgio Ciprandi

Michele Miraglia Del Giudice

Allergologia et Immunopathologia

ALLERGOLOGIA ET IMMUNOPATHOLOGIA 由 A. OEHLING 教授于 1972 年创立，是儿童哮喘、过敏和免疫学领域工作人员的论坛。与儿童相关的临床、流行病学和实验性过敏和免疫病理学相关的手稿将被考虑出版。 ALLERGOLOGIA ET IMMUNOPATHOLOGIA 是西班牙儿科过敏和临床免疫学学会 (SEICAP) 和拉丁美洲免疫缺陷学会 (LASID) 的官方期刊。它拥有独立的国际编辑委员会，将收到的论文提交给国际专家进行同行评审。该杂志接受来自世界各地的原创和评论文章，以及来自上述学会的共识声明。有时，专家对热门话题的意见会发表在“观点”部分。欢迎就以前发表的论文给编辑写信。 ALLERGOLOGIA ET IMMUNOPATHOLOGIA 每年出版 6 期，被 PUBMED、SCOPUS、WEB OF KNOWLEDGE 等主要数据库收录。

Allergologia et Immunopathologia was founded by Professor A. Oehling in 1972 as a forum for professionals in the fields of pediatric asthma, allergy, and immunology. The journal considers manuscripts related to clinical, epidemiological, and experimental allergy and immunopathology concerning children. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology (SEICAP) and the Latin American Society of Immunodeficiencies (LASID). It has an independent international editorial board that submits received papers for peer review by international experts. The journal welcomes original and review articles from around the world, as well as consensus statements from the aforementioned societies. Occasionally, expert opinions on hot topics are published in the 'Opinions' section. The editorial team also encourages correspondence regarding previously published papers. Allergologia et Immunopathologia is published six times a year and is indexed in major databases such as PUBMED, SCOPUS, and WEB OF KNOWLEDGE.

《Allergologia et Immunopathologia》由A. Oehling教授于1972年创立，是儿童哮喘、过敏和免疫学领域的专业论坛。该期刊欢迎与儿童相关的临床、流行病学和实验性过敏及免疫病理学的手稿投稿。《Allergologia et Immunopathologia》是西班牙儿科过敏与临床免疫学学会（SEICAP）和拉丁美洲免疫缺陷学会（LASID）的官方期刊。期刊拥有独立的国际编辑委员会，所有提交的论文均会送交国际专家进行同行评审。该杂志接受来自全球的原创研究和评论文章，以及上述学会的共识声明。此外，专家对热门话题的观点有时会在“观点”部分发表。编辑也欢迎就以前发表的论文进行交流。《Allergologia et Immunopathologia》每年出版6期，并被PUBMED、SCOPUS、WEB OF KNOWLEDGE等主要数据库收录。

Category	Quartile
医学	4
医学, 过敏	4
医学, 免疫学	4

Resveratrol plus carboxymethyl-β-glucan for children with respiratory diseases

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