Introduction: Xenon is a noble gas with unique properties that make it an attractive anesthetic agent. In addition to its anesthetic and analgesic effects, xenon has demonstrated organ-protective properties in preclinical studies, suggesting potential therapeutic applications beyond anesthesia. This review aims to systematically evaluate the available clinical evidence on the therapeutic use of xenon, focusing on its effects on various organ systems. Methods: A comprehensive literature search was conducted in medical databases including PubMed, Google Scholar, Cochrane Library, and eLIBRARY.RU. Original clinical studies evaluating the therapeutic use of xenon were included and analyzed. Results: The review identified several areas of potential therapeutic application for xenon: 1. Neuroprotection: Xenon has shown promise in reducing neurological injury and improving outcomes in patients with conditions such as cardiac arrest, traumatic brain injury, and neonatal hypoxic-ischemic encephalopathy. However, the clinical evidence remains limited, and larger randomized controlled trials are ongoing to further evaluate its efficacy. 2. Cardioprotection: Xenon has been found to attenuate myocardial injury and improve cardiac function in patients undergoing cardiac surgery or experiencing cardiac arrest, potentially through its anti-inflammatory and anti-apoptotic effects. 3. Addiction treatment: Inhalation of xenon has been investigated for its potential to alleviate withdrawal symptoms and cravings in patients with opioid and alcohol dependence, with some studies suggesting beneficial effects on cognitive function and mood. 4. Psychiatric applications: Preliminary evidence suggests that xenon may have anxiolytic and antidepressant properties, with potential applications in the treatment of panic disorder and other mood disorders. Conclusion: The available clinical data indicate that xenon may have therapeutic potential beyond its use as an anesthetic agent. However, further well-designed, large-scale studies are needed to establish the efficacy and safety of xenon in various clinical settings and to elucidate the underlying mechanisms of its organ-protective and psychoactive effects.

Mikhail Politov

Elizaveta Zolotova

Sofia Podprugina

Pavel Nogtev

Therapeutic Applications of Xenon (Literature Review).

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