While no vaccine can provide 100 percent protection, a high standard of regulatory safety, efficacy and quality is essential for public trust and the uptake of vaccines as essential global public health tools. This article addresses a growing concern that suboptimal “leaky” vaccines threaten emergency response to pandemics as well as routine public health programs. Agile regulatory standards now advance earlier approval of vaccines and therapeutics that may have suboptimal effectiveness. The benefit-harm trade- offs that play an enormous role in regulatory assessment and all stages of vaccine development and delivery deserve better public scrutiny, transparency, and accountability. Drawing on the case of the first licensed malaria vaccine, RTS,S Mosquirix™, in light of the rapid approval of COVID-19 vaccines, we consider the socio-technical implications of leaky vaccines in global vaccine logics and suggest possibilities for building legitimacy to inform the next generation of regulatory technology policy.

Janice Graham

Koen Peeters Grietens

Anthropologica

Anthropologica is the official publication of the Canadian Anthropology Society / Société canadienne d"anthropologie. A biannual journal, it publishes peer-reviewed articles in both French and English devoted to social and cultural issues whether they are pre-historic, historic, contemporary, biological, linguistic, applied or theoretical in orientation.

Anthropologica is the official publication of the Canadian Anthropology Society. This biannual journal publishes peer-reviewed articles in both French and English, focusing on social and cultural issues across various domains, including prehistoric, historical, contemporary, biological, linguistic, applied, and theoretical perspectives.

《Anthropologica》是加拿大人类学会的官方出版物。这本双年刊以法语和英语发表经过同行评审的文章，内容涉及社会和文化问题，包括史前、历史、当代、生物、语言、应用或理论等各个方向。

Leaky Vaccines: A Wicked Problem in Accelerated Vaccine Development

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