PD-L1 Expression and Its Regulation in Lung Adenocarcinoma with ALK Translocation.

Li Ma, Jialin Lv, Yujie Dong, Xinyong Zhang, Xi Li, Hui Zhang, Jingying Nong, Quan Zhang, Na Qin, Xinjie Yang, Jinghui Wang, Shucai Zhang

DOI: 10.1007/s12539-019-00331-0

Journal: Interdisciplinary sciences, computational life sciences

It is demonstrated that ALK translocation can upregulate PD-L1 expression by activating ERK, STAT3 and AKT pathways, which may be a potential strategy in ALK-translocated lung adenocarcinoma patients.