Abstract Bladder cancer is a urothelial cancer and effective therapeutic strategies for its advanced stages are limited. Here, we report that CD271, a neurotrophin receptor, promotes the proliferation and migration of bladder cancer cells. CD271 knockdown decreased proliferation in both adherent and spheroid cultures, and vice versa when CD271 was overexpressed in bladder cancer cell lines. CD271 depletion impaired tumorigenicity in vivo. Migration activity was reduced by CD271 knockdown and TAT‐Pep5, a known CD271‐Rho GDI‐binding inhibitor. Apoptosis was induced by CD271 knockdown. Comprehensive gene expression analysis revealed alterations in E2F‐ and Myc‐related pathways upon CD271 expression. In clinical cases, patients with high CD271 expression showed significantly shortened overall survival. In surgically resected specimens, pERK, a known player in proliferation signaling, colocalizes with CD271. These data indicate that CD271 is involved in bladder cancer malignancy by promoting cell proliferation and migration, resulting in poor prognosis.

Shingo Myoen

Mai Mochizuki

Rie Shibuya‐Takahashi

Haruna Fujimori

Norihisa Shindo

Kazunori Yamaguchi

Jun Yasuda

Jiro Abe

Takayuki Imai

Ikuro Sato

Hisanobu Adachi

Sadafumi Kawamura

Akihiro Ito

Keiichi Tamai

Genes to Cells

GENES TO CELLS 为发表描述分子和细胞生物学重要方面的论文提供了一个国际论坛。该杂志旨在发表在相关领域提供概念性进展的论文。将特别强调旨在了解生物学事件的基本机制的工作。

Genes to Cells is an international forum dedicated to publishing important research papers in the field of molecular and cellular biology. The journal aims to present conceptual advancements in related areas, with a particular emphasis on studies that seek to understand the fundamental mechanisms underlying biological events.

《Genes to Cells》是一个国际论坛，专注于发表分子和细胞生物学领域的重要研究论文。该杂志旨在发布在相关领域内提供概念性进展的研究成果，特别强调揭示生物学事件基本机制的研究工作。

<scp>CD271</scp> promotes proliferation and migration in bladder cancer

CD271, a neurotrophin receptor, promotes the proliferation and migration of bladder cancer cells and is involved in bladder cancer malignancy by promoting cell proliferation and migration, resulting in poor prognosis.

Category	Quartile
生物学	4
生物学, 细胞生物学	4
生物学, 遗传学	4

CD271 promotes proliferation and migration in bladder cancer

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Journal Info

Category	Quartile
GENETICS & HEREDITY	4